Title:
METHOD FOR VIRUS PROPAGATION
Document Type and Number:
WIPO Patent Application WO2003008533
Kind Code:
A3
Abstract:
The present invention relates to a process for producing poxvirus, in particular Chordopoxvirus, wherein the poxvirus is cultivated at a temperature below 37°C. The process leads to increased virus propagation at the decreased temperature.
Inventors:
HOWLEY PAUL (DE)
HELLER KARL (DE)
RAETHE INGMAR (DE)
HELLER KARL (DE)
RAETHE INGMAR (DE)
Application Number:
PCT/EP2002/007280
Publication Date:
January 08, 2004
Filing Date:
July 02, 2002
Export Citation:
Assignee:
BAVARIAN NORDIC AS (DK)
HOWLEY PAUL (DE)
HELLER KARL (DE)
RAETHE INGMAR (DE)
HOWLEY PAUL (DE)
HELLER KARL (DE)
RAETHE INGMAR (DE)
International Classes:
A01N63/00; A61K39/12; C12N7/00; A61K39/275; A61K39/285; A61K48/00; A61P31/12; A61P39/00; C07H21/04; C12M3/00; C12N7/01; C12N7/02; C12Q1/70; A61K39/00; C12N; (IPC1-7): C12N7/02; A61K35/76; A61K39/285
Foreign References:
| US4567147A | 1986-01-28 | |||
| US5616487A | 1997-04-01 |
Other References:
SLONIM D ET AL: "Influence of the incubation temperature on the dynamics of reproduction and plaque formation of three strains of Vaccinia virus in cell cultures.", JOURNAL OF HYGIENE, EPIDEMIOLOGY, MICROBIOLOGY, AND IMMUNOLOGY. CZECHOSLOVAKIA 1972, vol. 16, no. 4, 1972, pages 473 - 479, XP009013966, ISSN: 0022-1732
SLONIM D ET AL: "REPRODUCTION IN CHICK CHORIO ALLANTOIC MEMBRANE AND LETHAL EFFECT IN CHICK EMBRYOS OF 3 STRAINS OF VACCINIA VIRUS IN RELATION TO THE INCUBATION TEMPERATURE", JOURNAL OF HYGIENE EPIDEMIOLOGY MICROBIOLOGY AND IMMUNOLOGY (PRAGUE), vol. 17, no. 1, 1973, pages 21 - 25, XP009014033, ISSN: 0022-1732
SLONIM D ET AL: "Relation of infectious and lethal activities of three strains of Vaccinia virus to the incubation temperature.", JOURNAL OF HYGIENE, EPIDEMIOLOGY, MICROBIOLOGY, AND IMMUNOLOGY. CZECHOSLOVAKIA 1972, vol. 16, no. 4, 1972, pages 480 - 485, XP009014035, ISSN: 0022-1732
FUCHS N ET AL: "Virus isolation and titration at 33 degrees and 37 degrees C.", MEDICAL MICROBIOLOGY AND IMMUNOLOGY. GERMANY, WEST 1975, vol. 161, no. 2, 1975, pages 123 - 126, XP009014034, ISSN: 0300-8584
MINGLE J A ET AL: "Maintenance of primary African green monkey kidney (pAGMK) and Vero cells at room temperature (25 degrees). A system for virus isolation in community practice.", CANADIAN JOURNAL OF MICROBIOLOGY. CANADA MAR 1974, vol. 20, no. 3, March 1974 (1974-03-01), pages 391 - 397, XP009014036, ISSN: 0008-4166
SUGIMOTO M ET AL: "Characteristics of an attenuated vaccinia virus strain, LC16m0, and its recombinant virus vaccines.", VACCINE. ENGLAND JUN 1994, vol. 12, no. 8, June 1994 (1994-06-01), pages 675 - 681, XP009014044, ISSN: 0264-410X
SUTTER G ET AL: "NONREPLICATING VACCINIA VECTOR EFFICIENTLY EXPRESSES RECOMBINANT GENES", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 89, November 1992 (1992-11-01), pages 10847 - 10851, XP001036843, ISSN: 0027-8424
SLONIM D ET AL: "REPRODUCTION IN CHICK CHORIO ALLANTOIC MEMBRANE AND LETHAL EFFECT IN CHICK EMBRYOS OF 3 STRAINS OF VACCINIA VIRUS IN RELATION TO THE INCUBATION TEMPERATURE", JOURNAL OF HYGIENE EPIDEMIOLOGY MICROBIOLOGY AND IMMUNOLOGY (PRAGUE), vol. 17, no. 1, 1973, pages 21 - 25, XP009014033, ISSN: 0022-1732
SLONIM D ET AL: "Relation of infectious and lethal activities of three strains of Vaccinia virus to the incubation temperature.", JOURNAL OF HYGIENE, EPIDEMIOLOGY, MICROBIOLOGY, AND IMMUNOLOGY. CZECHOSLOVAKIA 1972, vol. 16, no. 4, 1972, pages 480 - 485, XP009014035, ISSN: 0022-1732
FUCHS N ET AL: "Virus isolation and titration at 33 degrees and 37 degrees C.", MEDICAL MICROBIOLOGY AND IMMUNOLOGY. GERMANY, WEST 1975, vol. 161, no. 2, 1975, pages 123 - 126, XP009014034, ISSN: 0300-8584
MINGLE J A ET AL: "Maintenance of primary African green monkey kidney (pAGMK) and Vero cells at room temperature (25 degrees). A system for virus isolation in community practice.", CANADIAN JOURNAL OF MICROBIOLOGY. CANADA MAR 1974, vol. 20, no. 3, March 1974 (1974-03-01), pages 391 - 397, XP009014036, ISSN: 0008-4166
SUGIMOTO M ET AL: "Characteristics of an attenuated vaccinia virus strain, LC16m0, and its recombinant virus vaccines.", VACCINE. ENGLAND JUN 1994, vol. 12, no. 8, June 1994 (1994-06-01), pages 675 - 681, XP009014044, ISSN: 0264-410X
SUTTER G ET AL: "NONREPLICATING VACCINIA VECTOR EFFICIENTLY EXPRESSES RECOMBINANT GENES", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 89, November 1992 (1992-11-01), pages 10847 - 10851, XP001036843, ISSN: 0027-8424
Download PDF: