Title:
METHOD
Document Type and Number:
WIPO Patent Application WO2006027545
Kind Code:
A3
Abstract:
We provide a method comprising modulating the activity of mTOR in a stem cell, preferably increasing the activity of mTOR to enable a stem cell to self-renew, or decreasing it to enable a stem cell to differentiate. The stem cell may be exposed to an agonist of mTOR for the former, preferably phosphatidic acid, or an antagonist of mTOR for the latter, preferably 1-butanol or rapamycin or a derivative thereof.
Inventors:
LIM SAI KIANG (SG)
QUE JIAN WEN (SG)
EL OAKLEY REIDA MENSHAWE (SG)
QUE JIAN WEN (SG)
EL OAKLEY REIDA MENSHAWE (SG)
Application Number:
PCT/GB2005/003206
Publication Date:
April 27, 2006
Filing Date:
August 17, 2005
Export Citation:
Assignee:
AGENCY SCIENCE TECH & RES (SG)
LIM SAI KIANG (SG)
QUE JIAN WEN (SG)
EL OAKLEY REIDA MENSHAWE (SG)
LIM SAI KIANG (SG)
QUE JIAN WEN (SG)
EL OAKLEY REIDA MENSHAWE (SG)
International Classes:
A01K67/027; A61K31/045; A61K31/436; A61K31/661; A61K38/45; C12N5/0735; C12N5/074; G01N33/50
Domestic Patent References:
| WO2002080975A1 | 2002-10-17 | |||
| WO2004089369A2 | 2004-10-21 |
Other References:
MURAKAMI MIREI ET AL: "mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells.", MOLECULAR AND CELLULAR BIOLOGY. AUG 2004, vol. 24, no. 15, August 2004 (2004-08-01), pages 6710 - 6718, XP002365723, ISSN: 0270-7306
FENG L X ET AL: "Stem cell factor/c-kit up-regulates cyclin D3 and promotes cell cycle progression via the phosphoinositide 3-kinase/p70 S6 kinase pathway in spermatogonia.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. 18 AUG 2000, vol. 275, no. 33, 18 August 2000 (2000-08-18), pages 25572 - 25576, XP002365724, ISSN: 0021-9258
DAS A V ET AL: "C - Kit receptor plays an important role in the maintenance of the adult neural stem cells: interaction with Notch signaling.", SOCIETY FOR NEUROSCIENCE ABSTRACT VIEWER AND ITINERARY PLANNER, vol. 2003, 2003, & 33RD ANNUAL MEETING OF THE SOCIETY OF NEUROSCIENCE; NEW ORLEANS, LA, USA; NOVEMBER 08-12, 2003, pages Abstract No. 452.12 URL - http://sf, XP009060950
MITA MONICA M ET AL: "The molecular target of rapamycin (mTOR) as a therapeutic target against cancer.", CANCER BIOLOGY & THERAPY. 2003 JUL-AUG, vol. 2, no. 4 Suppl 1, July 2003 (2003-07-01), pages S169 - S177, XP009060677, ISSN: 1538-4047
RAJAN PRITHI ET AL: "BMPs signal alternately through a SMAD or FRAP-STAT pathway to regulate fate choice in CNS stem cells.", THE JOURNAL OF CELL BIOLOGY. 9 JUN 2003, vol. 161, no. 5, 9 June 2003 (2003-06-09), pages 911 - 921, XP002365725, ISSN: 0021-9525
FENG L X ET AL: "Stem cell factor/c-kit up-regulates cyclin D3 and promotes cell cycle progression via the phosphoinositide 3-kinase/p70 S6 kinase pathway in spermatogonia.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. 18 AUG 2000, vol. 275, no. 33, 18 August 2000 (2000-08-18), pages 25572 - 25576, XP002365724, ISSN: 0021-9258
DAS A V ET AL: "C - Kit receptor plays an important role in the maintenance of the adult neural stem cells: interaction with Notch signaling.", SOCIETY FOR NEUROSCIENCE ABSTRACT VIEWER AND ITINERARY PLANNER, vol. 2003, 2003, & 33RD ANNUAL MEETING OF THE SOCIETY OF NEUROSCIENCE; NEW ORLEANS, LA, USA; NOVEMBER 08-12, 2003, pages Abstract No. 452.12 URL - http://sf, XP009060950
MITA MONICA M ET AL: "The molecular target of rapamycin (mTOR) as a therapeutic target against cancer.", CANCER BIOLOGY & THERAPY. 2003 JUL-AUG, vol. 2, no. 4 Suppl 1, July 2003 (2003-07-01), pages S169 - S177, XP009060677, ISSN: 1538-4047
RAJAN PRITHI ET AL: "BMPs signal alternately through a SMAD or FRAP-STAT pathway to regulate fate choice in CNS stem cells.", THE JOURNAL OF CELL BIOLOGY. 9 JUN 2003, vol. 161, no. 5, 9 June 2003 (2003-06-09), pages 911 - 921, XP002365725, ISSN: 0021-9525
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