Title:
METHODS FOR ACCELERATING BONE AND CARTILAGE GROWTH AND REPAIR
Document Type and Number:
WIPO Patent Application WO2000002905
Kind Code:
A3
Abstract:
The present invention provides improved methods, kits, and compositions for enhancing bone, cartilage and cartilage repair, bone and prosthesis implantation, and attachment and fixation of cartilage and cartilage to bone or other tissues, and chondrocyte proliferation comprising the administration of an effective amount of angiotensinogen, angiotensin I (AI), AI analogues, AI fragments and analogues thereof, angiotensin II (AII), AII analogues, AII fragments or analogues thereof or AII AT2 type 2 receptor agonists.
Inventors:
RODGERS KATHLEEN (US)
DIZEREGA GERE (US)
DIZEREGA GERE (US)
Application Number:
PCT/US1999/015735
Publication Date:
February 24, 2000
Filing Date:
July 12, 1999
Export Citation:
Assignee:
UNIV SOUTHERN CALIFORNIA (US)
RODGERS KATHLEEN (US)
DIZEREGA GERE (US)
RODGERS KATHLEEN (US)
DIZEREGA GERE (US)
International Classes:
A61K38/00; A61K38/18; C12N5/10; A61K38/22; A61K38/27; A61K38/29; A61K38/30; A61P19/00; A61P19/04; A61P19/08; A61P43/00; C07K7/00; C07K7/06; C07K7/14; C12N5/077; A61K35/12; (IPC1-7): A61K38/08; C07K7/14; C12N5/06
Domestic Patent References:
| WO1999046285A2 | 1999-09-16 | |||
| WO1996039164A1 | 1996-12-12 | |||
| WO1996014858A1 | 1996-05-23 |
Other References:
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; HAGIWARA, MITSUHIDE ET AL.: "Regulation of bone metabolism by vasoactive peptides", XP002900711, retrieved from STN FILE CA Database accession no. 129:36502
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; LAMPARTER, S. ET AL.: "Effects of angiotensin II on bone cells in vitro", XP002900712, retrieved from MEDLINE accession no. 1998150748
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; HATTON, R. ET AL.: "Angiotensin II is generated from angiotensin I by bone cells and stimulates osteoclastic bone resorption in vitro", XP002900713, retrieved from STN accession no. 127:1149
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; LAMPARTER, S. ET AL.: "Effects of angiotensin II on bone cells in vitro", XP002900712, retrieved from MEDLINE accession no. 1998150748
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; HATTON, R. ET AL.: "Angiotensin II is generated from angiotensin I by bone cells and stimulates osteoclastic bone resorption in vitro", XP002900713, retrieved from STN accession no. 127:1149
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