Title:
METHODS AND ACELLULAR COMPOSITIONS FOR TREATING INFLAMMATORY DISORDERS
Document Type and Number:
WIPO Patent Application WO/2014/149266
Kind Code:
A3
Abstract:
Acellular compositions for treating inflammation, comprising two or more of IL1-ra, sTNF-R1, sTNF-RII, IGF-I, EGF, HGF, PDGF-AB, PDGF-BB, VEGF, TGF-β1, and sIL-1RII. Components of the acellular compositions may be derived from biologic materials, such as blood clots and urine. Components may also be obtained from cell cultures.
Inventors:
WOODELL-MAY JENNIFER E (US)
HIGGINS JOEL C (US)
LEACH MICHAEL D (US)
O'SHAUGHNESSEY KRISTA (US)
HIGGINS JOEL C (US)
LEACH MICHAEL D (US)
O'SHAUGHNESSEY KRISTA (US)
Application Number:
PCT/US2014/016384
Publication Date:
November 20, 2014
Filing Date:
February 14, 2014
Export Citation:
Assignee:
BIOMET BIOLOGICS LLC (US)
International Classes:
A61P1/00; A61K38/00; A61P9/00; A61P19/00; A61P19/02; A61P19/10; A61P23/00; A61P25/00
Domestic Patent References:
| WO1991008285A1 | 1991-06-13 |
Other References:
FEIGE U ET AL: "Anti-interleukin-1 and anti-tumor necrosis factor-alpha synergistically inhibit adjuvant arthritis in Lewis rats", CMLS CELLULAR AND MOLECULAR LIFE SCIENCES, BIRKHAUSER VERLAG, HEIDELBERG, DE, vol. 57, no. 10, 1 September 2000 (2000-09-01), pages 1457 - 1470, XP002229548, ISSN: 1420-682X
BENDELE ALISON M ET AL: "COMBINATION BENEFIT OF TREATMENT WITH THE CYTOKINE INHIBITORS INTERLEUKIN-1 RECEPTOR ANTAGONIST AND PEGYLATED SOLUBLE TUMOR NECROSIS FACTOR RECEPTOR TYPE I IN ANIMAL MODELS OF RHEUMATOID ARTHRITIS", ARTHRITIS & RHEUMATISM, J.B. LIPPINCOTT CO, vol. 43, no. 12, 1 December 2000 (2000-12-01), pages 2648 - 2659, XP009073840, ISSN: 0004-3591, DOI: 10.1002/1529-0131(200012)43:12<2648::AID-ANR4>3.0.CO;2-M
CALDWELL, J.R.; OFFENBERG, H.; FURST, D.; LAM, N.P.; JAYNE, G.; JOH, T.; DAVIS, M.; EDWARDS, C.K. III.: "A phase I safety study of combination treatment with pegylated soluble tumor necrosis factor receptor type I (PET STNF-RI) and anakinra (interleukin-1 receptor antagonist, IL-1RA) in patients with rheumatoid arthritis", 12 June 2002 (2002-06-12), pages 1 - 1, XP002724516, Retrieved from the Internet [retrieved on 20140422]
KIMBLE ROBERT B ET AL: "Simultaneous block of interleukin-1 and tumor necrosis factor is required to completely prevent bone loss in the early postovariectomy period", ENDOCRINOLOGY, THE ENDOCRINE SOCIETY, US, vol. 136, no. 7, 1 July 1995 (1995-07-01), pages 3054 - 3061, XP009177708, ISSN: 0013-7227
SOLCHAGA L A ET AL: "HYALURONIC ACID-BASED POLYMERS AS CELL CARRIERS FOR TISSUE-ENGINEERED REPAIR OF BONE AND CARTILAGE", JOURNAL OF ORTHOPAEDIC RESEARCH, ORTHOPAEDIC RESEARCH SOCIETY, US, vol. 17, 1 January 1999 (1999-01-01), pages 205 - 213, XP002937764, ISSN: 0736-0266, DOI: 10.1002/JOR.1100170209
SANJAY MEHTA ET AL: "Gentamicin distribution from a collagen carrier", JOURNAL OF ORTHOPAEDIC RESEARCH, vol. 14, no. 5, 1 September 1996 (1996-09-01), pages 749 - 754, XP055118622, ISSN: 0736-0266, DOI: 10.1002/jor.1100140511
KITAZAWA R ET AL: "INTERLEUKIN-1 RECEPTOR ANTAGONIST AND TUMOR NECROSIS FACTOR BINDING PROTEIN DECREASE OSTEOCLAST FORMATION AND BONE RESORPTION IN OVARIECTOMIZED MICE", JOURNAL OF CLINICAL INVESTIGATION, AMERICAN SOCIETY FOR CLINICAL INVESTIGATION, US, vol. 94, no. 6, 1 December 1994 (1994-12-01), pages 2397 - 2406, XP001095290, ISSN: 0021-9738, DOI: 10.1172/JCI117606
ANONYMOUS: "Arthritis", 22 January 2013 (2013-01-22), pages 1 - 3, XP002724517, Retrieved from the Internet [retrieved on 20140424]
K. OKUNISHI ET AL: "Hepatocyte Growth Factor Significantly Suppresses Collagen-Induced Arthritis in Mice", THE JOURNAL OF IMMUNOLOGY, vol. 179, no. 8, 15 October 2007 (2007-10-15), pages 5504 - 5513, XP055115378, ISSN: 0022-1767, DOI: 10.4049/jimmunol.179.8.5504
DAWSON J ET AL: "Effects of soluble interleukin-1 type II receptor on rabbit antigen-induced arthritis: Clinical, biochemical and histological assessment", RHEUMATOLOGY (OXFORD), vol. 38, no. 5, May 1999 (1999-05-01), pages 401 - 406, XP002724518, ISSN: 1462-0324
BENDELE ALISON M ET AL: "COMBINATION BENEFIT OF TREATMENT WITH THE CYTOKINE INHIBITORS INTERLEUKIN-1 RECEPTOR ANTAGONIST AND PEGYLATED SOLUBLE TUMOR NECROSIS FACTOR RECEPTOR TYPE I IN ANIMAL MODELS OF RHEUMATOID ARTHRITIS", ARTHRITIS & RHEUMATISM, J.B. LIPPINCOTT CO, vol. 43, no. 12, 1 December 2000 (2000-12-01), pages 2648 - 2659, XP009073840, ISSN: 0004-3591, DOI: 10.1002/1529-0131(200012)43:12<2648::AID-ANR4>3.0.CO;2-M
CALDWELL, J.R.; OFFENBERG, H.; FURST, D.; LAM, N.P.; JAYNE, G.; JOH, T.; DAVIS, M.; EDWARDS, C.K. III.: "A phase I safety study of combination treatment with pegylated soluble tumor necrosis factor receptor type I (PET STNF-RI) and anakinra (interleukin-1 receptor antagonist, IL-1RA) in patients with rheumatoid arthritis", 12 June 2002 (2002-06-12), pages 1 - 1, XP002724516, Retrieved from the Internet
KIMBLE ROBERT B ET AL: "Simultaneous block of interleukin-1 and tumor necrosis factor is required to completely prevent bone loss in the early postovariectomy period", ENDOCRINOLOGY, THE ENDOCRINE SOCIETY, US, vol. 136, no. 7, 1 July 1995 (1995-07-01), pages 3054 - 3061, XP009177708, ISSN: 0013-7227
SOLCHAGA L A ET AL: "HYALURONIC ACID-BASED POLYMERS AS CELL CARRIERS FOR TISSUE-ENGINEERED REPAIR OF BONE AND CARTILAGE", JOURNAL OF ORTHOPAEDIC RESEARCH, ORTHOPAEDIC RESEARCH SOCIETY, US, vol. 17, 1 January 1999 (1999-01-01), pages 205 - 213, XP002937764, ISSN: 0736-0266, DOI: 10.1002/JOR.1100170209
SANJAY MEHTA ET AL: "Gentamicin distribution from a collagen carrier", JOURNAL OF ORTHOPAEDIC RESEARCH, vol. 14, no. 5, 1 September 1996 (1996-09-01), pages 749 - 754, XP055118622, ISSN: 0736-0266, DOI: 10.1002/jor.1100140511
KITAZAWA R ET AL: "INTERLEUKIN-1 RECEPTOR ANTAGONIST AND TUMOR NECROSIS FACTOR BINDING PROTEIN DECREASE OSTEOCLAST FORMATION AND BONE RESORPTION IN OVARIECTOMIZED MICE", JOURNAL OF CLINICAL INVESTIGATION, AMERICAN SOCIETY FOR CLINICAL INVESTIGATION, US, vol. 94, no. 6, 1 December 1994 (1994-12-01), pages 2397 - 2406, XP001095290, ISSN: 0021-9738, DOI: 10.1172/JCI117606
ANONYMOUS: "Arthritis", 22 January 2013 (2013-01-22), pages 1 - 3, XP002724517, Retrieved from the Internet
K. OKUNISHI ET AL: "Hepatocyte Growth Factor Significantly Suppresses Collagen-Induced Arthritis in Mice", THE JOURNAL OF IMMUNOLOGY, vol. 179, no. 8, 15 October 2007 (2007-10-15), pages 5504 - 5513, XP055115378, ISSN: 0022-1767, DOI: 10.4049/jimmunol.179.8.5504
DAWSON J ET AL: "Effects of soluble interleukin-1 type II receptor on rabbit antigen-induced arthritis: Clinical, biochemical and histological assessment", RHEUMATOLOGY (OXFORD), vol. 38, no. 5, May 1999 (1999-05-01), pages 401 - 406, XP002724518, ISSN: 1462-0324
Attorney, Agent or Firm:
SUTER, David L. et al. (Dickey & Pierce P.L.C.,P.O. Box 82, Bloomfield Hills Michigan, US)
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