Title:
METHODS AND AGENTS FOR MODULATING THE IMMUNE RESPONSE
Document Type and Number:
WIPO Patent Application WO/2023/034413
Kind Code:
A3
Abstract:
Described are agents and methods for modulating an immune response. More particularly, described are various agents and methods for selectively regulating expression of the gene Il12b in live animals, including human patients. Aberrant expression of Il12b is associated with autoinflammatory diseases including psoriasis, chronic eczema, vitiligo, lichen planus, systemic lupus erythematosus, Behçet's disease, and alopecia. Selective modulation of Il12b offers a new avenue for treatment of such diseases.
Inventors:
SMALE STEPHEN T (US)
SCUMPIA PHILIP O (US)
DAMOISEAUX ROBERT D (US)
DOTY KEVIN (US)
SCUMPIA PHILIP O (US)
DAMOISEAUX ROBERT D (US)
DOTY KEVIN (US)
Application Number:
PCT/US2022/042200
Publication Date:
April 13, 2023
Filing Date:
August 31, 2022
Export Citation:
Assignee:
UNIV CALIFORNIA (US)
International Classes:
A61K31/4709; A61K31/47; A61K31/4704; A61P1/04; A61P17/06; C07D333/10
Foreign References:
| US20150164910A1 | 2015-06-18 | |||
| US20130004458A1 | 2013-01-03 |
Other References:
M. NASI; S. DE BIASI; L. GIBELLINI; E. BIANCHINI; S. PECORINI; V. BACCA; G. GUARALDI; C. MUSSINI; M. PINTI; A. COSSARIZZA: "Ageing and inflammation in patients with HIV infection", CLINICAL AND EXPERIMENTAL IMMUNOLOGY, vol. 187, no. 1, 9 August 2016 (2016-08-09), GB , pages 44 - 52, XP071086466, ISSN: 0009-9104, DOI: 10.1111/cei.12814
FEUER RALPH, RULLER CHELSEA M., AN NAILI, TABOR-GODWIN JENNA M., RHOADES ROSS E., MACIEJEWSKI SONIA, PAGARIGAN ROBB R., CORNELL CH: "Viral Persistence and Chronic Immunopathology in the Adult Central Nervous System following Coxsackievirus Infection during the Neonatal Period", JOURNAL OF VIROLOGY, vol. 83, no. 18, 1 September 2009 (2009-09-01), pages 9356 - 9369, XP093061005, DOI: 10.1128/JVI.02382-07
NYSTRÖM NIKLAS, BERG TOVE, LUNDIN ELIN, SKOG OSKAR, HANSSON INGA, FRISK GUN, JUKO-PECIREP IVANA, NILSSON MATS, GYLLENSTEN ULF, FIN: "Human Enterovirus Species B in Ileocecal Crohn's Disease", CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY, vol. 4, no. 6, 1 June 2013 (2013-06-01), pages 1 - 7, XP093061009, DOI: 10.1038/ctg.2013.7
MORAR, N. ; WILLIS-OWEN, S.A. ; MAURER, T. ; BUNKER, C.B.: "HIV-associated psoriasis: pathogenesis, clinical features, and management", THE LANCET INFECTIOUS DISEASES, vol. 10, no. 7, 1 July 2010 (2010-07-01), AMSTERDAM, NL , pages 470 - 478, XP027598818, ISSN: 1473-3099, DOI: 10.1016/S1473-3099(10)70101-8
FEUER RALPH, RULLER CHELSEA M., AN NAILI, TABOR-GODWIN JENNA M., RHOADES ROSS E., MACIEJEWSKI SONIA, PAGARIGAN ROBB R., CORNELL CH: "Viral Persistence and Chronic Immunopathology in the Adult Central Nervous System following Coxsackievirus Infection during the Neonatal Period", JOURNAL OF VIROLOGY, vol. 83, no. 18, 1 September 2009 (2009-09-01), pages 9356 - 9369, XP093061005, DOI: 10.1128/JVI.02382-07
NYSTRÖM NIKLAS, BERG TOVE, LUNDIN ELIN, SKOG OSKAR, HANSSON INGA, FRISK GUN, JUKO-PECIREP IVANA, NILSSON MATS, GYLLENSTEN ULF, FIN: "Human Enterovirus Species B in Ileocecal Crohn's Disease", CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY, vol. 4, no. 6, 1 June 2013 (2013-06-01), pages 1 - 7, XP093061009, DOI: 10.1038/ctg.2013.7
MORAR, N. ; WILLIS-OWEN, S.A. ; MAURER, T. ; BUNKER, C.B.: "HIV-associated psoriasis: pathogenesis, clinical features, and management", THE LANCET INFECTIOUS DISEASES, vol. 10, no. 7, 1 July 2010 (2010-07-01), AMSTERDAM, NL , pages 470 - 478, XP027598818, ISSN: 1473-3099, DOI: 10.1016/S1473-3099(10)70101-8
Attorney, Agent or Firm:
COHEN, Mark S. et al. (US)
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