Title:
METHODS AND APPARATUS FOR IMAGING WITH MULTIMODE OPTICAL FIBERS
Document Type and Number:
WIPO Patent Application WO/2013/144898
Kind Code:
A3
Abstract:
A multimode waveguide illuminator and imager relies on a wave front shaping system that acts to compensate for modal scrambling and light dispersion by the multimode waveguide. A first step consists of calibrating the multimode wave¬ guide and a second step consists in projecting a specific pattern on the wave¬ guide proximal end in order to produce the desire light pattern at its distal end. The illumination pattern can be scanned or changed dynamically only by chang¬ ing the phase pattern projected at the proximal end of the waveguide. The third and last step consists in collecting the optical information, generated by the sample, through the same waveguide in order to form an image. Known free space microscopy technique can be adapted to endoscopy with multimode waveguide, such as, but not limited to, fluorescence imaging or Raman spectros¬ copy or imaging, 3D linear scattering imaging or two-photon imaging. Super- resolution, i.e., resolution below the diffraction limit, is achieved for example but not limited to, using the STimulated Emission Depletion microscopy (STED) technique or the Structured Illumination Microscopy (SIM) technique or a stochastic illumination based method (PALM, STORM) in combination with the multimode waveguide imaging method.
Inventors:
PAPADOPOULOS IOANNIS (CH)
FARAHI SALMA (CH)
MOSER CHRISTOPHE (CH)
PSALTIS DEMETRI (CH)
FARAHI SALMA (CH)
MOSER CHRISTOPHE (CH)
PSALTIS DEMETRI (CH)
Application Number:
PCT/IB2013/052493
Publication Date:
January 23, 2014
Filing Date:
March 28, 2013
Export Citation:
Assignee:
ECOLE POLYTECH (CH)
International Classes:
F21V8/00; G02B6/028; G03H1/00
Domestic Patent References:
| WO2010004297A1 | 2010-01-14 |
Foreign References:
| US20040212799A1 | 2004-10-28 | |||
| US5956447A | 1999-09-21 | |||
| US20040125380A1 | 2004-07-01 | |||
| US7194155B1 | 2007-03-20 |
Other References:
DATABASE INSPEC [online] THE INSTITUTION OF ELECTRICAL ENGINEERS, STEVENAGE, GB; 26 September 2011 (2011-09-26), CIZMAR T ET AL: "Shaping the light transmission through a multimode optical fibre: complex transformation analysis and applications in biophotonics", XP002705793, Database accession no. 12320328
DATABASE INSPEC [online] THE INSTITUTION OF ELECTRICAL ENGINEERS, STEVENAGE, GB; January 2011 (2011-01-01), DI LEONARDO R ET AL: "Hologram transmission through multi-mode optical fibers", XP002705794, Database accession no. 11775938
DATABASE INSPEC [online] THE INSTITUTION OF ELECTRICAL ENGINEERS, STEVENAGE, GB; January 2011 (2011-01-01), DI LEONARDO R ET AL: "Hologram transmission through multi-mode optical fibers", XP002705794, Database accession no. 11775938
Attorney, Agent or Firm:
WEIHS, Bruno (P.O. Box 5107, Lausanne, CH)
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