METHODS FOR ASSAYING T-CELL DEPENDENT BISPECIFIC ANTIBODIES

Title:

METHODS FOR ASSAYING T-CELL DEPENDENT BISPECIFIC ANTIBODIES

Document Type and Number:

WIPO Patent Application WO/2017/132279

Kind Code:

A8

Abstract:

The present invention provides a cell-based assay for measuring T cell activation mediated by a T cell -dependent bispecific antibody (TDB). In some aspects, the assay is useful for detecting a TDB in a composition, quantitating the amount of TDB in a composition, determining the potency and/or specificity of a TDB, or determining if a population of cells expresses a target antigen. Compositions and kits are also contemplated.

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Inventors:

LEE HO (US)
JIANG GUOYING (US)
WONG PIN (US)
CAREY KENDALL (US)

Application Number:

PCT/US2017/014974

Publication Date:

June 28, 2018

Filing Date:

January 25, 2017

Export Citation:

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Assignee:

GENENTECH INC (US)
HOFFMANN LA ROCHE (CH)

International Classes:

G01N33/50; C07K16/08

Attorney, Agent or Firm:

DONAHUE, Brian A. et al. (US)

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