Title:
METHODS FOR ASSESSING ENDOMETRIAL RECEPTIVITY OF A PATIENT AFTER CONTROLLED OVARIAN HYPERSTIMULATION
Document Type and Number:
WIPO Patent Application WO/2013/057316
Kind Code:
A3
Abstract:
The present invention relates to methods and kits for assessing the endometrial receptivity of a patient after controlled ovarian hyperstimulation. More particularly, the invention relates to a method for assessing the endometrial receptivity of a patient after controlled ovarian hyperstimulation, comprising a step consisting of measuring the expression level of at least one gene selected from fifteen genes in an endometrial biopsy sample obtained from said patient wherein said genes are FGFBP1, MUC20, TMPRSS3, PRUNE2, HES2, MGST1, ERRFI1, EDN1, SLC17A7, MET, CPT1B, DCDC2, LRRC39, IL18RAP, and FOXP1.
Inventors:
HAMAMAH SAMIR (FR)
HAOUZI DELPHINE (FR)
HAOUZI DELPHINE (FR)
Application Number:
PCT/EP2012/070892
Publication Date:
June 06, 2013
Filing Date:
October 22, 2012
Export Citation:
Assignee:
INST NAT SANTE RECH MED (FR)
International Classes:
C12Q1/68
Other References:
HAOUZI D ET AL.: "Gene expression profile of human endometrial receptivity: comparison between natural and stimulated cycles for the same patients", HUMAN REPRODUCTION, vol. 24, no. 6, 2009, pages 1436 - 1445, XP002671341
HAOUZI D ET AL.: "Controlled ovarian hyperstimulation for in vitro fertilization alters endometrial receptivity in humans: protocol effects", BIOLOGY OF REPRODUCTION, vol. 82, 2010, pages 679 - 686, XP002671342
HAOUZI D ET AL.: "Transcriptome analysis reveals dialogues between human trophectoderm and endometrial cells during the implantation period", HUMAN REPRODUCTION, vol. 26, no. 6, 2011, pages 1440 - 1449, XP002671343
CHANG S Y ET AL.: "Expression of steroid receptors, their cofactors, and aromatase in human luteinized granulosa cells after controlled ovarian hyperstimulation", FERTILITY & STERILITY, vol. 83, no. Suppl.1, April 2005 (2005-04-01), pages 1241 - 1247, XP002671344
DIAZ-GIMENO P ET AL: "A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature", FERTILITY AND STERILITY, vol. 95, no. 1, 1 January 2011 (2011-01-01), ELSEVIER SCIENCE INC, NEW YORK, NY, USA, pages 50 - 60.E15, XP027563196, ISSN: 0015-0282, [retrieved on 20100708]
OUANDAGOGO Z G ET AL.: "Human cumulus cells molecular signature in relation to oocyte nuclear maturity stage", PLOS ONE, vol. 6, no. 11, E27179, November 2011 (2011-11-01), pages 1 - 6, XP002671345
HAOUZI D ET AL.: "Controlled ovarian hyperstimulation for in vitro fertilization alters endometrial receptivity in humans: protocol effects", BIOLOGY OF REPRODUCTION, vol. 82, 2010, pages 679 - 686, XP002671342
HAOUZI D ET AL.: "Transcriptome analysis reveals dialogues between human trophectoderm and endometrial cells during the implantation period", HUMAN REPRODUCTION, vol. 26, no. 6, 2011, pages 1440 - 1449, XP002671343
CHANG S Y ET AL.: "Expression of steroid receptors, their cofactors, and aromatase in human luteinized granulosa cells after controlled ovarian hyperstimulation", FERTILITY & STERILITY, vol. 83, no. Suppl.1, April 2005 (2005-04-01), pages 1241 - 1247, XP002671344
DIAZ-GIMENO P ET AL: "A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature", FERTILITY AND STERILITY, vol. 95, no. 1, 1 January 2011 (2011-01-01), ELSEVIER SCIENCE INC, NEW YORK, NY, USA, pages 50 - 60.E15, XP027563196, ISSN: 0015-0282, [retrieved on 20100708]
OUANDAGOGO Z G ET AL.: "Human cumulus cells molecular signature in relation to oocyte nuclear maturity stage", PLOS ONE, vol. 6, no. 11, E27179, November 2011 (2011-11-01), pages 1 - 6, XP002671345
Attorney, Agent or Firm:
HIRSCH, Denise (Paris, FR)
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