Title:
METHODS FOR ATTENUATING PARASITE VIRULENCE
Document Type and Number:
WIPO Patent Application WO/2017/055925
Kind Code:
A3
Abstract:
Pharmaceutical compositions and methods for the treatment of malaria are presented. Such compositions and methods may target energy-sensing pathways of the malaria parasite, Plasmoclium, of parasite host cell, or both. The compositions, in certain aspects of the present invention, target a signalling pathway involving the host AMP-protein activated kinase (AMPK) and/or the parasite AMPK homologue, KIN, which controls parasite replication and virulence.
Inventors:
SILVA LILIANA MANCIO (PT)
DIAS DA MOTA MARIA MANUEL (PT)
DIAS DA MOTA MARIA MANUEL (PT)
Application Number:
PCT/IB2016/001523
Publication Date:
June 01, 2017
Filing Date:
September 30, 2016
Export Citation:
Assignee:
INST DE MEDICINA MOLECULAR (PT)
International Classes:
A61K31/155; A61P33/06
Domestic Patent References:
| WO2011121109A1 | 2011-10-06 | |||
| WO2012114204A2 | 2012-08-30 | |||
| WO2000076517A1 | 2000-12-21 |
Foreign References:
| US20070105945A1 | 2007-05-10 | |||
| GB727151A | 1955-03-30 | |||
| US2594309A | 1952-04-29 |
Other References:
REDDY R C ET AL: "Curcumin for malaria therapy", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM, NL, vol. 326, no. 2, 14 January 2005 (2005-01-14), pages 472 - 474, XP004682832, ISSN: 0006-291X, DOI: 10.1016/J.BBRC.2004.11.051
AMITA MISHRA ET AL: "Thiourea and Guanidine Derivatives as Antimalarial and Antimicrobial Agents ", CURRENT TOPICS IN MEDICINAL CHEMISTRY, vol. 13, no. 16, 1 September 2013 (2013-09-01), HILVERSUM; NL, pages 2011 - 2025, XP055346233, ISSN: 1568-0266, DOI: 10.2174/15680266113139990126
AMITA MISHRA ET AL: "Thiourea and Guanidine Derivatives as Antimalarial and Antimicrobial Agents ", CURRENT TOPICS IN MEDICINAL CHEMISTRY, vol. 13, no. 16, 1 September 2013 (2013-09-01), HILVERSUM; NL, pages 2011 - 2025, XP055346233, ISSN: 1568-0266, DOI: 10.2174/15680266113139990126
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