Title:
METHODS OF CANCER TREATMENT USING ANTI-PD1 ANTIBODIES IN COMBINATION WITH ANTI-TIM3 ANTIBODIES AND ANTI-LAG3 ANTIBODIES
Document Type and Number:
WIPO Patent Application WO/2024/041651
Kind Code:
A1
Abstract:
The present disclosure provides a method of cancer treatment or enhancing an immune response, the method comprising administering to a patient an effective amount of an anti-PD1 antibody or antigen-binding fragment thereof in combination with an anti-TIM3 antibody or antigen binding fragment thereof and an anti-LAG3 antibody or antigen binding fragment thereof.
Inventors:
ZHANG JIYUAN (CN)
JIN WEI (CN)
DING XIAO (CN)
ZHU HENGRUI (CN)
GAO HUA-XIN (US)
ZHENG WENJUAN (CN)
MU SONG (US)
WONG GILBERT (US)
JIN WEI (CN)
DING XIAO (CN)
ZHU HENGRUI (CN)
GAO HUA-XIN (US)
ZHENG WENJUAN (CN)
MU SONG (US)
WONG GILBERT (US)
Application Number:
PCT/CN2023/115062
Publication Date:
February 29, 2024
Filing Date:
August 25, 2023
Export Citation:
Assignee:
BEIGENE LTD (GB)
ZHANG JIYUAN (CN)
ZHANG JIYUAN (CN)
International Classes:
C07K16/30; A61K39/395; A61P35/00; A61P37/02
Foreign References:
| CN110621698A | 2019-12-27 | |||
| CN109790218A | 2019-05-21 | |||
| CN110914303A | 2020-03-24 | |||
| CN112457403A | 2021-03-09 |
Other References:
KOSAKU MIMURA ET AL.: "Combined inhibition of PD-1/PD-L1, Lag-3, and Tim-3 axes augments antitumor immunity in gastric cancer-T cell coculture models", GASTRIC CANCER., vol. 24, no. 3, 20 February 2021 (2021-02-20), XP037431895, DOI: 10.1007/s10120-020-01151-8
Attorney, Agent or Firm:
WU, FENG & ZHANG (CN)
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