Title:
METHODS OF CANCER TREATMENT USING A COMBINATION OF BTK INHIBITORS AND PI3 KINASE INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2023/040810
Kind Code:
A1
Abstract:
Disclosed herein is a method for the treatment or delay of progression of cancer in a subject, comprising administering to the subject in need thereof a BTK inhibitor, for example, (S) -7- (1-acryloylpiperidin-4-yl) -2- (4-phenoxyphenyl) -4, 5, 6, 7-tetra-hydropyrazolo [1, 5-a] pyrimidine-3-carboxamide or a pharmaceutically acceptable salt thereof, in combination with a PI3Kδ inhibitor or a pharmaceutically acceptable salt thereof.
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Inventors:
SONG XIAOMIN (CN)
YANG XIAO (CN)
HU NAN (CN)
LIU YUAN (CN)
LI JING (CN)
WANG ZHIWEI (CN)
YANG XIAO (CN)
HU NAN (CN)
LIU YUAN (CN)
LI JING (CN)
WANG ZHIWEI (CN)
Application Number:
PCT/CN2022/118351
Publication Date:
March 23, 2023
Filing Date:
September 13, 2022
Export Citation:
Assignee:
BEIGENE LTD (GB)
SONG XIAOMIN (CN)
SONG XIAOMIN (CN)
International Classes:
A61K45/00; A61K31/395; A61K31/4162; A61K31/435; A61K31/519; A61P35/00
Domestic Patent References:
| WO2018033135A1 | 2018-02-22 | |||
| WO2019047915A1 | 2019-03-14 | |||
| WO2018103688A1 | 2018-06-14 |
Other References:
JIANGCHUAN TAO: "Combined treatment of BTK and PI3K inhibitors synergistically disrupts BCR-signaling, overcomes microenviroment-mediated survival and drug resistance in mantle cell lymphoma", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 73, no. 8_Supplement, 10 April 2013 (2013-04-10) - 10 April 2013 (2013-04-10), US, pages 4944, XP055129363, ISSN: 0008-5472, DOI: 10.1158/1538-7445.AM2013-4944
Attorney, Agent or Firm:
WU, FENG & ZHANG (CN)
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