Title:
METHODS OF CHARACTERIZING ADRENOCORTICAL TUMORS
Document Type and Number:
WIPO Patent Application WO/2017/004237
Kind Code:
A8
Abstract:
Disclosed herein are methods of diagnosing and treating a malignant adrenocortical tumor, including adrenocortical carcinoma. In some examples, methods of diagnosing a malignant adrenocortical tumor include measuring creatine riboside, L-tryptophan, Νε,Νε,Νε-trimethyl-L-lysine and 3-methylhistidine in a biological sample obtained from a subject with an adrenocortical tumor and identifying an increase in creatine riboside and a decrease in L-tryptophan, Νε,Νε,Νε-trimethyl-L-lysine and 3-methylhistidine in the biological sample when compared to a control or reference value for each molecule indicates a malignant adrenocortical tumor. Methods of treatment and evaluating the effectiveness of an agent for treating a malignant adrenocortical tumor are also disclosed. Additionally, kits, assays and devices for characterizing adrenocortical tumors are provided.
Inventors:
PATEL DHAVAL T (US)
KRAUSZ KRISTOPHER W (US)
GONZALEZ FRANK J (US)
KEBEBEW ELECTRON (US)
THOMPSON MATTHEW (US)
KRAUSZ KRISTOPHER W (US)
GONZALEZ FRANK J (US)
KEBEBEW ELECTRON (US)
THOMPSON MATTHEW (US)
Application Number:
PCT/US2016/040148
Publication Date:
February 09, 2017
Filing Date:
June 29, 2016
Export Citation:
Assignee:
US HEALTH (US)
International Classes:
G01N33/574; G01N33/68
Attorney, Agent or Firm:
SCOTT, Gregory, K. (US)
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