Title:
METHODS FOR CHEMICALLY INDUCED LINEAGE REPROGRAMMING
Document Type and Number:
WIPO Patent Application WO/2018/218480
Kind Code:
A1
Abstract:
Provided are chemical inducers of lineage reprogramming (CiLR) which include glycogen synthase kinase inhibitors, TGFβ receptor inhibitors, cyclic AMP agonists or histone acetylators. Also provided is a method of inducing lineage reprograming in a partially or completely differentiated cell of a first type into a cell with characteristics of a second and different lineage. The method includes: contacting a cell with the CiLR for a sufficient period of time to result in reprograming the cell into a modified XEN-like cell which is subsequently programmed into a cell with characteristics of a second and different lineage.
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Inventors:
DENG HONGKUI (CN)
LI XIANG (CN)
LIU DEFANG (CN)
MA YANTAO (CN)
DU XIAOMIN (CN)
LI XIANG (CN)
LIU DEFANG (CN)
MA YANTAO (CN)
DU XIAOMIN (CN)
Application Number:
PCT/CN2017/086545
Publication Date:
December 06, 2018
Filing Date:
May 31, 2017
Export Citation:
Assignee:
BEIHAO STEM CELL AND REGENERATIVE MEDICINE RES INSTITUTE CO LTD (CN)
HONG GUAN LTD (CN)
HONG GUAN LTD (CN)
International Classes:
C12N5/071; C12N5/0735; C12N5/0793
Foreign References:
| CN104278008A | 2015-01-14 | |||
| CN105039258A | 2015-11-11 | |||
| CN102260646A | 2011-11-30 | |||
| US8637494B2 | 2014-01-28 | |||
| US8236299B2 | 2012-08-07 | |||
| US20080206733A1 | 2008-08-28 | |||
| US6962814B2 | 2005-11-08 | |||
| US7914579B2 | 2011-03-29 | |||
| US5716404A | 1998-02-10 | |||
| US8728495B2 | 2014-05-20 | |||
| US20090029322A1 | 2009-01-29 | |||
| US20060019326A1 | 2006-01-26 | |||
| US20070059293A1 | 2007-03-15 |
Other References:
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MHANNA ET AL., TISSUE ENGINEERING PART A, vol. 20, no. 7-8, 2014, pages 1165 - 74
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XIN ET AL., PLOS ONE, 12 January 2016 (2016-01-12)
LIU, CELL RES., vol. 24, no. 10, 2014, pages 1181 - 1200
BALLADUR ET AL., SURGERY, vol. 117, 1995, pages 189 - 94
DIXIT ET AL., CELL TRANSPLANTATION, vol. 1, 1992, pages 275 - 79
SHAPIRO ET AL., N ENGL J MED., vol. 343, no. 4, 2000, pages 230 - 8
ZHOU ET AL., LIVER TRANSPL., vol. 17, no. 4, 2011, pages 418 - 27
WILLERTH, S.M.SAKIYAMA-ELBERT, S.E.: "Combining stem cells and biomaterial scaffolds for constructing tissues and cell delivery", 9 July 2008, THE STEM CELL RESEARCH COMMUNITY
SHU ET AL., CELL, vol. 153, 2013, pages 963 - 975
BAR-NUR ET AL., NAT BIOTECHNOL., vol. 33, 2015, pages 761 - 768
KUO ET AL., J. MED. CHEM., vol. 6, 2003, pages 4021 - 4031
CAI ET AL., HEPATOLOGY, vol. 45, 2007, pages 1229 - 1239
SONG ET AL., CELL RES., vol. 19, 2009, pages 1233 - 1242
See also references of EP 3630948A4
ZHANG ET AL., CELL STEM CELL, vol. 17, 2015, pages 195 - 203
ZHAO YANG ET AL., CELL, vol. 163, no. 7, 2015, pages 1678 - 1691
LEE ET AL., CHEM AND BIOL., vol. 13, 2006, pages 563 - 567
ZHOU ET AL., CHEM BIOL. AND DRUG DESIGN, vol. 85, no. 6, 2015, pages 659 - 671
SCHMIDTT ET AL., J. MED. CHEM., vol. 56, no. 18, 2013, pages 7334 - 7342
PAREKH ET AL., NEURON, vol. 77, no. 6, 2013, pages 1017 - 1038
HO ET AL., BMC BIOINFORMATICS, vol. 12, 2011, pages 230
IZANT ET AL., PROC NATL ACAD SCI USA, vol. 77, 1980, pages 4741 - 5
MULLEN ET AL., DEVELOPMENT, vol. 116, 1992, pages 201 - 11
WOJCIK ET AL., PNAS, vol. 18, 2004, pages 7158 - 7163
KANAANI ET AL., J. CELL. BIOL., vol. 190, no. 5, pages 911 - 925
VIERBUCHEN ET AL., NATURE, vol. 463, 2010, pages 1035 - 1041
YOO ET AL., NATURE, vol. 476, no. 7359, 2011, pages 228 - 31
AMBASUDHAN ET AL., CELL STEM CELL, vol. 9, no. 2, 2001, pages 113 - 118
BANERRJEE ET AL., PLOS ONE, vol. 7, no. 3, 2012, pages e33165
MHANNA ET AL., TISSUE ENGINEERING PART A, vol. 20, no. 7-8, 2014, pages 1165 - 74
YANG ET AL., J. BIOMED. SCI., vol. 18, 2011, pages 59
XIN ET AL., PLOS ONE, 12 January 2016 (2016-01-12)
LIU, CELL RES., vol. 24, no. 10, 2014, pages 1181 - 1200
BALLADUR ET AL., SURGERY, vol. 117, 1995, pages 189 - 94
DIXIT ET AL., CELL TRANSPLANTATION, vol. 1, 1992, pages 275 - 79
SHAPIRO ET AL., N ENGL J MED., vol. 343, no. 4, 2000, pages 230 - 8
ZHOU ET AL., LIVER TRANSPL., vol. 17, no. 4, 2011, pages 418 - 27
WILLERTH, S.M.SAKIYAMA-ELBERT, S.E.: "Combining stem cells and biomaterial scaffolds for constructing tissues and cell delivery", 9 July 2008, THE STEM CELL RESEARCH COMMUNITY
SHU ET AL., CELL, vol. 153, 2013, pages 963 - 975
BAR-NUR ET AL., NAT BIOTECHNOL., vol. 33, 2015, pages 761 - 768
KUO ET AL., J. MED. CHEM., vol. 6, 2003, pages 4021 - 4031
CAI ET AL., HEPATOLOGY, vol. 45, 2007, pages 1229 - 1239
SONG ET AL., CELL RES., vol. 19, 2009, pages 1233 - 1242
See also references of EP 3630948A4
Attorney, Agent or Firm:
CHINA SCIENCE PATENT & TRADEMARK AGENT LTD. (CN)
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