Title:
METHODS AND COMPOSITIONS FOR ADMINISTERING RECOMBINANT VIRAL VECTORS
Document Type and Number:
WIPO Patent Application WO/2022/006253
Kind Code:
A3
Abstract:
Provided herein are methods of transducing a recombinant viral, e.g., retroviral, vector, improving the transgene expression from a recombinant viral vector, and reducing titers of neutralizing antibodies that bind a recombinant viral vector. In general, these methods include administering to a subject a recombinant viral vector and an effective amount of an immunosuppressive regimen.
Inventors:
YUEN ERIC (US)
TANG YINGHUA (US)
YANG ZIYING (US)
ENGELHARDT JOHN F (US)
TANG YINGHUA (US)
YANG ZIYING (US)
ENGELHARDT JOHN F (US)
Application Number:
PCT/US2021/039860
Publication Date:
February 24, 2022
Filing Date:
June 30, 2021
Export Citation:
Assignee:
UNIV IOWA RES FOUND (US)
YUEN ERIC (US)
YUEN ERIC (US)
International Classes:
A61K48/00; A61K31/573; A61K38/13; A61P11/00
Domestic Patent References:
| WO2015164758A1 | 2015-10-29 | |||
| WO2017155973A1 | 2017-09-14 | |||
| WO2020214668A1 | 2020-10-22 |
Other References:
FEDERICO MINGOZZI ET AL: "Pharmacological Modulation of Humoral Immunity in a Nonhuman Primate Model of AAV Gene Transfer for Hemophilia B", MOLECULAR THERAPY, vol. 20, no. 7, 8 May 2012 (2012-05-08), US, pages 1410 - 1416, XP055265154, ISSN: 1525-0016, DOI: 10.1038/mt.2012.84
CASSIVI ET AL: "Transgene expression after adenovirus-mediated retransfection of rat lungs is increased and prolonged by transplant immunosuppression", THE JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, MOSBY-YEAR BOOK, INC., ST. LOUIS, MO, US, vol. 117, no. 1, 1 January 1999 (1999-01-01), pages 1 - 7, XP005693644, ISSN: 0022-5223, DOI: 10.1016/S0022-5223(99)70462-9
TANG Y ET AL: "Study of the neutralizing antibody after rAAV.TL65 transduction in ferret airway", PEDIATRIC PULMONOLOGY; 33RD ANNUAL NORTH AMERICAN CYSTIC FIBROSIS CONFERENCE 20191031 TO 20191102 NASHVILLE, TN, JOHN WILEY & SONS, INC, US, vol. 54, no. Supplement 2, 1 October 2019 (2019-10-01), pages 325, XP009521880, ISSN: 1099-0496, DOI: 10.1002/PPUL.22495
CARMEN UNZU ET AL: "Transient and intensive pharmacological immunosuppression fails to improve AAV-based liver gene transfer in non-human primates", JOURNAL OF TRANSLATIONAL MEDICINE, BIOMED CENTRAL, vol. 10, no. 1, 15 June 2012 (2012-06-15), pages 122, XP021133139, ISSN: 1479-5876, DOI: 10.1186/1479-5876-10-122
ASHLEY COONEY ET AL: "Cystic Fibrosis Gene Therapy: Looking Back, Looking Forward", GENES, vol. 9, no. 11, 7 November 2018 (2018-11-07), pages 538, XP055690547, DOI: 10.3390/genes9110538
TANG Y ET AL: "435: Immunosuppressants improve the transduction of AAV2.5T after repeat dosing of ferret lungs", PEDIATRIC PULMONOLOGY; 34TH ANNUAL NORTH AMERICAN CYSTIC FIBROSIS CONFERENCE; 20201007 TO 20201023; PHOENIX, AZ, USA, JOHN WILEY & SONS, INC, US, vol. 55, no. SUPPL 2, 1 October 2020 (2020-10-01), pages 208, XP009531014, ISSN: 1099-0496, [retrieved on 20201006], DOI: 10.1002/PPUL.25089
CASSIVI ET AL: "Transgene expression after adenovirus-mediated retransfection of rat lungs is increased and prolonged by transplant immunosuppression", THE JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, MOSBY-YEAR BOOK, INC., ST. LOUIS, MO, US, vol. 117, no. 1, 1 January 1999 (1999-01-01), pages 1 - 7, XP005693644, ISSN: 0022-5223, DOI: 10.1016/S0022-5223(99)70462-9
TANG Y ET AL: "Study of the neutralizing antibody after rAAV.TL65 transduction in ferret airway", PEDIATRIC PULMONOLOGY; 33RD ANNUAL NORTH AMERICAN CYSTIC FIBROSIS CONFERENCE 20191031 TO 20191102 NASHVILLE, TN, JOHN WILEY & SONS, INC, US, vol. 54, no. Supplement 2, 1 October 2019 (2019-10-01), pages 325, XP009521880, ISSN: 1099-0496, DOI: 10.1002/PPUL.22495
CARMEN UNZU ET AL: "Transient and intensive pharmacological immunosuppression fails to improve AAV-based liver gene transfer in non-human primates", JOURNAL OF TRANSLATIONAL MEDICINE, BIOMED CENTRAL, vol. 10, no. 1, 15 June 2012 (2012-06-15), pages 122, XP021133139, ISSN: 1479-5876, DOI: 10.1186/1479-5876-10-122
ASHLEY COONEY ET AL: "Cystic Fibrosis Gene Therapy: Looking Back, Looking Forward", GENES, vol. 9, no. 11, 7 November 2018 (2018-11-07), pages 538, XP055690547, DOI: 10.3390/genes9110538
TANG Y ET AL: "435: Immunosuppressants improve the transduction of AAV2.5T after repeat dosing of ferret lungs", PEDIATRIC PULMONOLOGY; 34TH ANNUAL NORTH AMERICAN CYSTIC FIBROSIS CONFERENCE; 20201007 TO 20201023; PHOENIX, AZ, USA, JOHN WILEY & SONS, INC, US, vol. 55, no. SUPPL 2, 1 October 2020 (2020-10-01), pages 208, XP009531014, ISSN: 1099-0496, [retrieved on 20201006], DOI: 10.1002/PPUL.25089
Attorney, Agent or Firm:
PERDOK, Monique M. et al. (US)
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