METHODS, COMPOSITIONS, AND APPARATUSES FOR FORMING MACROCYCLIC COMPOUNDS

Title:

METHODS, COMPOSITIONS, AND APPARATUSES FOR FORMING MACROCYCLIC COMPOUNDS

Document Type and Number:

WIPO Patent Application WO2006025859

Kind Code:

A3

Abstract:

This invention relates to methods, compositions, and apparatuses for producing macrocyclic compounds. First, one or more reactants are provided in a reaction medium, which are capable of forming the macrocyclic compound through a desired reaction pathway that includes at least cyclization, and which are further capable of forming undesired oligomers through a undesired reaction pathway that includes undesirable oligomerization. Oligomerization of such reactions in the reaction medium is modulated to reduce formation of undesired oligomers and/or to reduce separation of the undesired oligomers from the reaction medium, relative to a corresponding unmodulated oligomerization reaction, thereby maximizing yields of the macrocyclic compound. The macrocyclic compound so formed is then recovered from the reaction medium. Preferably, the macrocyclic compound spontaneously separates from the reaction medium via phase separation. More preferably, the macrocyclic compound spontaneous precipitates from the reaction medium and therefore can be easily recovered by simple filtration.

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Inventors:

JOHNSON THOMAS E (US)
FOWLER BILLY T (US)

Application Number:

PCT/US2005/005028

Publication Date:

November 23, 2006

Filing Date:

February 17, 2005

Export Citation:

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Assignee:

JOHNSON THOMAS E (US)
FOWLER BILLY T (US)

International Classes:

A61K31/40; C07B47/00; A61K31/555

Foreign References:

US6610351B2

2003-08-26

Other References: