Title:
METHODS, COMPOSITIONS AND COMPOUND ASSAYS FOR INHIBITING AMYLOID-BETA PROTEIN PRODUCTION
Document Type and Number:
WIPO Patent Application WO2005108949
Kind Code:
A3
Abstract:
A method for identifying compounds that inhibit amyloid-beta precursor protein processing in cells, comprising contacting a test compound with a PROTEASE polypeptide, or fragment thereof, and measuring a compound-PROTEASE property related to the production of amyloid-beta peptide. Cellular assays of the method measure indicators including cleaved protease substrate and/or amyloid beta peptide levels. Therapeutic methods, and pharmaceutical compositions including effective amyloid-beta precursor processing-inhibiting amounts of PROTEASE expression inhibitors, are useful for treating conditions involving cognitive impairment such as Alzheimer's disease.
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Inventors:
SPITTAELS KOENRAAD FREDERIK FL (BE)
HOFFMANN MARCEL (NL)
MERCHIERS PASCAL GERARD (BE)
HOFFMANN MARCEL (NL)
MERCHIERS PASCAL GERARD (BE)
Application Number:
PCT/EP2005/052186
Publication Date:
July 20, 2006
Filing Date:
May 12, 2005
Export Citation:
Assignee:
GALAPAGOS NV (BE)
LAENEN WENDY (BE)
SPITTAELS KOENRAAD FREDERIK FL (BE)
HOFFMANN MARCEL (NL)
MERCHIERS PASCAL GERARD (BE)
LAENEN WENDY (BE)
SPITTAELS KOENRAAD FREDERIK FL (BE)
HOFFMANN MARCEL (NL)
MERCHIERS PASCAL GERARD (BE)
International Classes:
G01N33/68; A61K48/00; C12Q1/00; C12Q1/25; C12Q1/48; C12Q1/68; G01N33/53; G01N33/567; G01N33/74; G01N
Domestic Patent References:
| WO2000078934A2 | 2000-12-28 |
Foreign References:
| EP0972837A2 | 2000-01-19 |
Other References:
ANNAERT WIM ET AL: "A cell biological perspective on Alzheimer's disease.", ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY. VOLUME 18 ANNUAL REVIEWS, 4139 EL CAMINO WAY, P. O. BOX 10139, PALO ALTO, CA, 94303-0139, USA SERIES : ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY (ISSN 1081-0706 (ISSN PRINT)), 2002, pages 25 - 51, XP002352008, ISSN: 0-8243-3119-4
MERCHIERS P ET AL: "A HIGH THROUGHPUT CELL-BASED SCREEN FOR IDENTICATION OF PUTATIVE ALZHEIMER'S DISEASE MODIFYING DRUGABLE GENES THAT MODULATE AMYLOID LEVELS", SOCIETY FOR NEUROSCIENCE ABSTRACTS, SOCIETY FOR NEUROSCIENCE, US, 8 November 2003 (2003-11-08), pages ABSTRNO44511, XP001183924, ISSN: 0190-5295
MERCHIERS P ET AL: "A HIGH THROUGHPUT CELL-BASED SCREEN FOR IDENTICATION OF PUTATIVE ALZHEIMER'S DISEASE MODIFYING DRUGABLE GENES THAT MODULATE AMYLOID LEVELS", SOCIETY FOR NEUROSCIENCE ABSTRACTS, SOCIETY FOR NEUROSCIENCE, US, 8 November 2003 (2003-11-08), pages ABSTRNO44511, XP001183924, ISSN: 0190-5295
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