Title:
METHODS AND COMPOSITIONS FOR DECREASING ALLERGIC REACTIONS TO SURFACE ALLERGENS
Document Type and Number:
WIPO Patent Application WO2000035484
Kind Code:
A3
Abstract:
IgE binding epitopes on allergens which induce allergic symptoms following surface contact, such as those associated with latex rubber and cat allergies, among others, can be blocked. Molecules which bind to these epitopes can be identified and synthesized and then formulated to coat or blend with the allergenic surface to prevent patient IgE from gaining access to the allergenic epitopes. In one embodiment, the molecules are antibodies or antibody fragments which selectively bind to the epitopes that elicit the allergic response. In another embodiment, the masking reagents are peptides which mimic antibody fragments and bind to the relevant epitopes on the allergens. In a third embodiment, the cDNAs encoding Fab fragments which bind to the relevant antigens are isolated and the Fab proteins encoded by these cDNAs are prepared.
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Inventors:
CAPLAN MICHAEL (US)
SOSIN HOWARD (US)
SOSIN HOWARD (US)
Application Number:
PCT/US1999/030238
Publication Date:
October 19, 2000
Filing Date:
December 17, 1999
Export Citation:
Assignee:
CAPLAN MICHAEL (US)
SOSIN HOWARD (US)
SOSIN HOWARD (US)
International Classes:
A61K9/14; A61K39/395; A61K9/08; A61K45/00; A61P37/08; A61P43/00; C07K16/16; C07K16/18; (IPC1-7): A61K39/395; A61P37/08
Domestic Patent References:
| WO1995012420A1 | 1995-05-11 | |||
| WO1995007933A1 | 1995-03-23 |
Foreign References:
| US5670626A | 1997-09-23 |
Other References:
BARTELL et al, "Automatic Combination of Multiple Ranked Retrieval Systems", Proceedings of SIGIR '94, July 1994, pages 173-181 XP002919510
BELKIN et al,"The Effect of Multiple Queri Representations on Information System Performance", Proceedings of SIGIR '93, June 1993, pages 339-346 XP002919511
SHAW et al, "Combination of Multiple Searches", Proceedings of TREC-3, April 1995, pages 105-108 XP002919512
QUARTERDECK WEB PAGE, DOWNLOADED, 9 September 1996, http://www.aracnid.qdeck.com/qdeck/ products/webcompass. XP002919513
TOWELL et al, "Learning Collection Fusion Strategies for Information Retrieval", Proceedings of the 12th Annual Machine Learning Conference, July 1995, pages 540-548 XP002919514
VOORHEES et al, "Learning Collection Fusion Strategies", Proceedings of SIGIR '95, July 1995, pages 172-179 XP002919515
VOORHEES et al, "The Collection Fusion Problem", Proceedings of TREC-3, NIST Special Publication 500-225, April 1995, pages 95-104 XP002919516
BELKIN et al,"The Effect of Multiple Queri Representations on Information System Performance", Proceedings of SIGIR '93, June 1993, pages 339-346 XP002919511
SHAW et al, "Combination of Multiple Searches", Proceedings of TREC-3, April 1995, pages 105-108 XP002919512
QUARTERDECK WEB PAGE, DOWNLOADED, 9 September 1996, http://www.aracnid.qdeck.com/qdeck/ products/webcompass. XP002919513
TOWELL et al, "Learning Collection Fusion Strategies for Information Retrieval", Proceedings of the 12th Annual Machine Learning Conference, July 1995, pages 540-548 XP002919514
VOORHEES et al, "Learning Collection Fusion Strategies", Proceedings of SIGIR '95, July 1995, pages 172-179 XP002919515
VOORHEES et al, "The Collection Fusion Problem", Proceedings of TREC-3, NIST Special Publication 500-225, April 1995, pages 95-104 XP002919516
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