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Title:
METHODS AND COMPOSITIONS FOR DELIVERY OF MEDICAMENTS TO THE LUNGS
Document Type and Number:
WIPO Patent Application WO/2010/068754
Kind Code:
A3
Abstract:
The disclosure provides a drug composition formulated for inhalation comprising a conjugate of a surface active agent and a pulmonary active drug. The surface active agent has an affinity for the human alveolar/gas interface and comprises at least a portion of a mammalian lung surfactant of a mimic thereof. The disclosure also provides a method of treating a subject suffering from or at risk of suffering from a lung disease comprising administering to the subject a conjugate comprising a drug for lung treatment and a surface active agent by inhalation in an amount effective to induce a drug effect in the lungs.

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Inventors:
GUARNIERI FRANK (US)
Application Number:
PCT/US2009/067499
Publication Date:
October 28, 2010
Filing Date:
December 10, 2009
Export Citation:
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Assignee:
PAKA PULMONARY PHARMACEUTICALS (US)
GUARNIERI FRANK (US)
International Classes:
A61K9/72; A61K47/42; A61P11/00
Domestic Patent References:
WO2008151235A22008-12-11
Foreign References:
US20050070477A12005-03-31
US20060234909A12006-10-19
US20060148693A12006-07-06
US20070225233A12007-09-27
US5006343A1991-04-09
US20070129297A12007-06-07
US20060147520A12006-07-06
Other References:
See also references of EP 2370068A4
Attorney, Agent or Firm:
STERN-DOMBAL, Charlene, A. et al. (Exchange PlaceBoston, MA, US)
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