METHODS AND COMPOSITIONS FOR ENHANCING THE EFFICACY AND SPECIFICITY OF RNA SILENCING

WIPO Patent Application WO2006015389

A3

The present invention provides methods of enhancing the efficacy and specificity of RNA silencing. The invention also provides compositions for mediating RNA silencing. In particular, the invention provides siRNAs, siRNA-like molecules, shRNAs, vectors and transgenes having improved specificity and efficacy in mediating silencing of a target gene. Therapeutic methods are also featured.

WO/2001/040521	NUCLEIC ACIDS CONTAINING SINGLE NUCLEOTIDE POLYMORPHISMS AND METHODS OF USE THEREOF
JP2002515871	[Title of the Invention] A novel LysS protein of Streptococcus pneumoniae
JP5186693	A viral vector that expresses a virus or gene that grows in hypoxic cells

ZAMORE PHILLIP D (US)
HUTVAGNER GYORGY (US)
SCHWARZ DIANNE (US)
SIMARD MARTIN (CA)

PCT/US2005/029011

June 15, 2006

August 04, 2005

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UNIV MASSACHUSETTS (US)
ZAMORE PHILLIP D (US)
HUTVAGNER GYORGY (US)
SCHWARZ DIANNE (US)
SIMARD MARTIN (CA)

A61K31/7088; A61K48/00; C12N15/11; C12N15/113; C12N15/85; C12Q1/68

HOHJOH H.: "Enhancement of RNAi activity by improved siRNA duplexes", FEBS LETTERS, vol. 557, 16 January 2004 (2004-01-16), pages 193 - 198, XP002365325
SCHWARZ D.S. ET AL.: "Asymmetry in the assembly of the RNAi enzyme complex", CELL, vol. 115, 17 October 2003 (2003-10-17), pages 199 - 208, XP002365326
KHVOROVA A. ET AL.: "Functional siRNAs and miRNAs exhibit strand bias", CELL, vol. 115, 17 October 2003 (2003-10-17), pages 209 - 216, XP002365327

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