METHODS AND COMPOSITIONS FOR ENHANCING AN IMMUNE RESPONSE, BLOCKING MONOCYTE MIGRATION, AMPLIFYING VACCINE IMMUNITY AND INHIBITING TUMOR GROWTH AND METASTASIS

Title:

METHODS AND COMPOSITIONS FOR ENHANCING AN IMMUNE RESPONSE, BLOCKING MONOCYTE MIGRATION, AMPLIFYING VACCINE IMMUNITY AND INHIBITING TUMOR GROWTH AND METASTASIS

Document Type and Number:

WIPO Patent Application WO/2014/134621

Kind Code:

A3

Abstract:

Provided are methods for enhancing an immune response, methods for decreasing monocyte recruitment to lymph nodes, and methods for amplifying vaccine immunity by administering to an individual various monocyte migration inhibitors alone or in combination, and optionally in conjunction with an antigen, vaccine, or anti-tumor preparation. The invention also provides related methods of inhibiting tumor growth and metastasis. In addition, related compositions comprising one or more monocyte migration inhibitors and optionally comprising antigens, vaccines, or anti-tumor preparations are provided, as are kits containing such compositions.

Inventors:

DOW STEVEN W (US)
REGAN DANIEL P (US)
GUTH AMANDA M (US)
MITCHELL LEAH (US)
PETRI MICHELINA (US)

Application Number:

PCT/US2014/020018

Publication Date:

November 06, 2014

Filing Date:

March 03, 2014

Export Citation:

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Assignee:

UNIV COLORADO STATE RES FOUND (US)

International Classes:

A61P31/12

Domestic Patent References:

WO2011053789A2	2011-05-05
WO2012030234A1	2012-03-08
WO2012094703A1	2012-07-19

Foreign References:

US20080194494A1

2008-08-14

Other References: