Title:
METHODS AND COMPOSITIONS FOR ENHANCING IN VIVO GENE DELIVERY/EXPRESSION
Document Type and Number:
WIPO Patent Application WO2000050584
Kind Code:
A3
Abstract:
A novel nucleotide expression delivery system is disclosed which provides for increased expression levels of such polynucleotides as well as continued persistence of the expression system in vivo. According to the invention, the expression system is contained within, impregnated in or associated with a biocompatible collagen based carrier composition. Methods and compositions for practicing the same are disclosed. The invention further includes the immunogenic properties of such compositions and use of the same for antigenic or vaccine protocols.
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Inventors:
RATLIFF TIMOTHY L
SIEMENS D ROBERT
AUSTIN J CHRISTOPHER
HEDICAN SEAN P
LUBAROFF DAVID M
ELZEY BENNETT D
SIEMENS D ROBERT
AUSTIN J CHRISTOPHER
HEDICAN SEAN P
LUBAROFF DAVID M
ELZEY BENNETT D
Application Number:
PCT/US2000/004530
Publication Date:
November 15, 2001
Filing Date:
February 23, 2000
Export Citation:
Assignee:
UNIV IOWA RES FOUND (US)
International Classes:
A61K38/19; A61K38/20; A61K39/00; A61K48/00; (IPC1-7): A61K48/00; A61K39/00; A61P35/00
Domestic Patent References:
| WO1994006922A1 | 1994-03-31 | |||
| WO1998052605A1 | 1998-11-26 | |||
| WO1998053799A2 | 1998-12-03 | |||
| WO1998004282A1 | 1998-02-05 |
Foreign References:
| US3469003A | 1969-09-23 |
Other References:
WALSH S M ET AL: "COMBINATION OF DRUG AND GENE DELIVERY BY GELATIN NANOSPHERES FOR THE TREATMENT OF CYSTIC FIBROSIS", PROCEEDINGS OF THE INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS,US,DEERFIELD, IL., CONTROLLED RELEASE SOC, vol. SYMP. 24, 15 June 1997 (1997-06-15), pages 75 - 76, XP002052415, ISSN: 1022-0178
LEONG K W ET AL: "DNA-polycation nanospheres as non-viral gene delivery vehicles", JOURNAL OF CONTROLLED RELEASE,NL,ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, vol. 53, no. 1-3, 30 April 1998 (1998-04-30), pages 183 - 193, XP004121269, ISSN: 0168-3659
TRUONG-LE V L ET AL: "DELIVERY OF DNA VACCINE USING GELATIN-DNA NANOSPHERES", PROCEEDINGS OF THE INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS,US,DEERFIELD, IL., CONTROLLED RELEASE SOC, vol. SYMP. 24, 15 June 1997 (1997-06-15), pages 39 - 40, XP002052416, ISSN: 1022-0178
KAWAKITA K ET AL: "EFFECT OF CANARYPOX VIRUS (ALVAC)-MEDIATED CYTOKINE EXPRESSION ON MURINE PROSTATE TUMOR GROWTH", JOURNAL OF THE NATIONAL CANCER INSTITUTE,US,US DEPT. OF HEALTH, EDICATIONAND WELFARE, PUBLIC HEALTH, vol. 89, no. 6, 19 March 1997 (1997-03-19), pages 428 - 436, XP002062563, ISSN: 0027-8874
SIEMENS D ROBERT ET AL: "Viral delivery in a gelatin sponge matrix enhances gene expression and antitumor activity in a murine prostate cancer model.", JOURNAL OF UROLOGY, vol. 161, no. 4 SUPPL., April 1999 (1999-04-01), 94th Annual Meeting of the American Urological Association, Inc.;Dallas, Texas, USA; May 1-6, 1999, pages 61, XP000939393, ISSN: 0022-5347
LEONG K W ET AL: "DNA-polycation nanospheres as non-viral gene delivery vehicles", JOURNAL OF CONTROLLED RELEASE,NL,ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, vol. 53, no. 1-3, 30 April 1998 (1998-04-30), pages 183 - 193, XP004121269, ISSN: 0168-3659
TRUONG-LE V L ET AL: "DELIVERY OF DNA VACCINE USING GELATIN-DNA NANOSPHERES", PROCEEDINGS OF THE INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS,US,DEERFIELD, IL., CONTROLLED RELEASE SOC, vol. SYMP. 24, 15 June 1997 (1997-06-15), pages 39 - 40, XP002052416, ISSN: 1022-0178
KAWAKITA K ET AL: "EFFECT OF CANARYPOX VIRUS (ALVAC)-MEDIATED CYTOKINE EXPRESSION ON MURINE PROSTATE TUMOR GROWTH", JOURNAL OF THE NATIONAL CANCER INSTITUTE,US,US DEPT. OF HEALTH, EDICATIONAND WELFARE, PUBLIC HEALTH, vol. 89, no. 6, 19 March 1997 (1997-03-19), pages 428 - 436, XP002062563, ISSN: 0027-8874
SIEMENS D ROBERT ET AL: "Viral delivery in a gelatin sponge matrix enhances gene expression and antitumor activity in a murine prostate cancer model.", JOURNAL OF UROLOGY, vol. 161, no. 4 SUPPL., April 1999 (1999-04-01), 94th Annual Meeting of the American Urological Association, Inc.;Dallas, Texas, USA; May 1-6, 1999, pages 61, XP000939393, ISSN: 0022-5347
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