Title:
METHODS AND COMPOSITIONS FOR THE GENERATION AND USE OF HUMANIZED CONFORMATION-SPECIFIC PHOSPHORYLATED TAU ANTIBODIES
Document Type and Number:
WIPO Patent Application WO/2019/094595
Kind Code:
A3
Abstract:
The present disclosure relates generally to conformation-specific antibodies that can bind to and neutralize the activity of phosphorylated-Threonine 231-tau protein (pT231-tau). The antibodies of the present technology are useful in methods for treating a neurological disorder associated with elevated cis-pT231-tau protein expression in a subject in need thereof.
Inventors:
KUMAR SHANKAR (US)
TSURUSHITA NAOYA (US)
AHLIJANIAN MICHAEL (US)
JEFSON MARTIN (US)
TSURUSHITA NAOYA (US)
AHLIJANIAN MICHAEL (US)
JEFSON MARTIN (US)
Application Number:
PCT/US2018/059833
Publication Date:
April 02, 2020
Filing Date:
November 08, 2018
Export Citation:
Assignee:
PINTEON THERAPEUTICS INC (US)
International Classes:
A61K39/395; C07K2/00; C07K16/18; G01N33/53
Domestic Patent References:
| WO2014152157A2 | 2014-09-25 |
Foreign References:
| US20120148592A1 | 2012-06-14 |
Other References:
See also references of EP 3706795A4
Attorney, Agent or Firm:
HAYS, Rebecca L. et al. (US)
Download PDF: