Title:
METHODS AND COMPOSITIONS FOR INHIBITING CLONAL HEMATOPOIESIS
Document Type and Number:
WIPO Patent Application WO/2024/050296
Kind Code:
A3
Abstract:
Clonal hematopoiesis is an age-related condition caused by somatic mutations that give a hematopoietic stem cell a clonal selective advantage. While clonal hematopoiesis is a benign condition, individuals affected by it have an increased risk of developing blood cancers, such as acute myeloid leukemia (AML). The present disclosure provides, in some aspects, methods for inhibiting clonal hematopoiesis using a senolytic agent to target senescence of bone marrow stromal cells.
Inventors:
TROWBRIDGE JENNIFER (US)
Application Number:
PCT/US2023/072977
Publication Date:
April 11, 2024
Filing Date:
August 28, 2023
Export Citation:
Assignee:
JACKSON LAB (US)
International Classes:
C12N5/077; A61P7/00; A61P35/02
Attorney, Agent or Firm:
JULIAN, Victoria L. et al. (US)
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