Title:
METHODS AND COMPOSITIONS FOR INHIBITION OF BROMODOMAIN AND EXTRATERMINAL PROTEINS
Document Type and Number:
WIPO Patent Application WO/2016/077656
Kind Code:
A3
Abstract:
The present invention relates to compounds that bind to and otherwise modulate the activity of bromodomain-containing proteins, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders.
Inventors:
YOSHIOKA MAKOTO (US)
STROVEL JEFFEREY WILLIAM (US)
PADIA JANAK KHIMCHAND (US)
STROVEL JEFFEREY WILLIAM (US)
PADIA JANAK KHIMCHAND (US)
Application Number:
PCT/US2015/060494
Publication Date:
August 25, 2016
Filing Date:
November 13, 2015
Export Citation:
Assignee:
CONVERGENE LLC (US)
International Classes:
C07D413/04; A61K31/422; A61K31/4725; A61P25/28; A61P35/00; C07D215/227; C07D215/40; C07D401/04; C07D413/14
Domestic Patent References:
| WO2014159837A1 | 2014-10-02 |
Other References:
TIWARI, ABHISHEK ET AL.: "Synthesis of new pyrazolidine 3,5 dione derivatives of potential analgesic, antipyretic and anti-inflammatory activities", MIDDLE-EAST JOURNAL OF SCIENTIFIC RESEARCH, vol. 17, no. 7, 2013, pages 926 - 93, XP009502881
UKRAINE TS, I. V. ET AL.: "4-HYDROXY-2-QUINOLONES. 192.* RELATIONSHIP OF STRUCTURE AND ANALGESIC ACTIVITY OF 4-AMINO-2-OXO-1,2-DIHYDROQUfMOLINE-3-CAR13OXYLIC ACIDS AND THEIR DERIVATIVES", CHEMISTRY OF HETEROCYCLIC COMPOUNDS, vol. 46, no. 11, pages 1371 - 1379, XP009502877
UKRAINE TS, 1. V. ET AL.: "4-HYDROXYQUINOL-2-ONES. 87*. UNUSUAL SYNTHESIS OF 1-R-4-HYDROXY-2-OXO-1,2-DIHYDROQUINOLINE-3-CARBOXYLIC ACID PYRIDYLAMIDES", CHEMISTRY OF HETEROCYCLIC COMPOUNDS, vol. 41, no. 9, 2005, pages 1158 - 1166, XP019276440
DATABASE Chemical Abstract compoun 19 April 2009 (2009-04-19), retrieved from STN Database accession no. 1136445-44-7
FARHANULLAH ET AL.: "Design and synthesis of quinolinones as methionyl-tRNA synthetase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 14, 2006, pages 7154 - 7159, XP005661663, DOI: doi:10.1016/j.bmc.2006.06.062
DATABASE Chemical Abstract compoun 6 December 2004 (2004-12-06), retrieved from STN Database accession no. 792868-63-4
See also references of EP 3218370A4
UKRAINE TS, I. V. ET AL.: "4-HYDROXY-2-QUINOLONES. 192.* RELATIONSHIP OF STRUCTURE AND ANALGESIC ACTIVITY OF 4-AMINO-2-OXO-1,2-DIHYDROQUfMOLINE-3-CAR13OXYLIC ACIDS AND THEIR DERIVATIVES", CHEMISTRY OF HETEROCYCLIC COMPOUNDS, vol. 46, no. 11, pages 1371 - 1379, XP009502877
UKRAINE TS, 1. V. ET AL.: "4-HYDROXYQUINOL-2-ONES. 87*. UNUSUAL SYNTHESIS OF 1-R-4-HYDROXY-2-OXO-1,2-DIHYDROQUINOLINE-3-CARBOXYLIC ACID PYRIDYLAMIDES", CHEMISTRY OF HETEROCYCLIC COMPOUNDS, vol. 41, no. 9, 2005, pages 1158 - 1166, XP019276440
DATABASE Chemical Abstract compoun 19 April 2009 (2009-04-19), retrieved from STN Database accession no. 1136445-44-7
FARHANULLAH ET AL.: "Design and synthesis of quinolinones as methionyl-tRNA synthetase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 14, 2006, pages 7154 - 7159, XP005661663, DOI: doi:10.1016/j.bmc.2006.06.062
DATABASE Chemical Abstract compoun 6 December 2004 (2004-12-06), retrieved from STN Database accession no. 792868-63-4
See also references of EP 3218370A4
Attorney, Agent or Firm:
BREINING, Scott R. (LLPP.O. Box 703, Atlanta GA, US)
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