Title:
METHODS AND COMPOSITIONS FOR THE INHIBITION OF CATHEPSINS
Document Type and Number:
WIPO Patent Application WO2005067958
Kind Code:
A3
Abstract:
Methods and compositions for modulating cell death by contacting a cell with an Spi2A polypeptide or an Spi2A polypeptide equivalent are disclosed. In addition, methods of treating a subject by providing the subject a composition that includes an Spi2A polypeptide or an Spi2A polypeptide equivalent are disclosed. The Spi2A polypeptide and Spi2A polypeptide equivalent can be delivered to the subject using gene therapy techniques. The subject can be a patient with a disease associated with an abnormal rate of cell death, such as septic shock or myocardial infarction. Also disclosed are methods of preparing and storing donor granulocytes, involving contacting the donor granulocytes with an Spi2A polypeptide or an Spi2A polypeptide equivalent.
Inventors:
ASHTON-RICKARDT PHILIP G (US)
Application Number:
PCT/US2004/004954
Publication Date:
September 15, 2005
Filing Date:
February 19, 2004
Export Citation:
Assignee:
UNIV CHICAGO (US)
ASHTON-RICKARDT PHILIP G (US)
ASHTON-RICKARDT PHILIP G (US)
International Classes:
A61K38/55; A61K38/57; C07K14/81; C12N5/06; (IPC1-7): A61K38/57; C12N5/06
Domestic Patent References:
| WO1999057273A2 | 1999-11-11 |
Foreign References:
| US20040214773A1 | 2004-10-28 |
Other References:
LIU N ET AL: "Serine protease inhibitor 2A inhibits caspase-independent cell death", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 569, no. 1-3, 2 July 2004 (2004-07-02), pages 49 - 53, XP004517458, ISSN: 0014-5793
GUICCIARDI MARIA EUGENIA ET AL: "Lysosomes in cell death.", ONCOGENE. 12 APR 2004, vol. 23, no. 16, 12 April 2004 (2004-04-12), pages 2881 - 2890, XP001205596, ISSN: 0950-9232
LIU NI ET AL: "Induction of a cathepsin B inhibitor by NF-kB blocks the lysosomal pathway of cell death.", FASEB JOURNAL, vol. 17, no. 7, 14 April 2003 (2003-04-14), & 90TH ANNIVERSARY ANNUAL MEETING OF THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS; DENVER, CO, USA; MAY 06-10, 2003, pages C152, XP009045219, ISSN: 0892-6638
LIU NI ET AL: "NF-kappaB protects from the lysosomal pathway of cell death.", EMBO (EUROPEAN MOLECULAR BIOLOGY ORGANIZATION) JOURNAL, vol. 22, no. 19, 1 October 2003 (2003-10-01), pages 5313 - 5322, XP001205586, ISSN: 0261-4189
BIRD P I: "Regulation of pro-apoptotic leucocyte granule serine proteinases by intracellular serpins.", IMMUNOLOGY AND CELL BIOLOGY. FEB 1999, vol. 77, no. 1, February 1999 (1999-02-01), pages 47 - 57, XP001205594, ISSN: 0818-9641
MORRIS EMMA C ET AL: "Nuclear localisation of haemopoietic serpin 2A: A potential regulatory of apoptosis", BRITISH JOURNAL OF HAEMATOLOGY, vol. 101, no. SUPPL. 1, May 1998 (1998-05-01), & ANNUAL SCIENTIFIC MEETING OF THE BRITISH SOCIETY FOR HAEMATOLOGY; GLASGOW, SCOTLAND, UK; APRIL 27-30, 1998, pages 27, XP009045220, ISSN: 0007-1048
HAMERMAN JESSICA A ET AL: "Serpin 2a is induced in activated macrophages and conjugates to a ubiquitin homolog", JOURNAL OF IMMUNOLOGY, vol. 168, no. 5, 1 March 2002 (2002-03-01), pages 2415 - 2423, XP009045212, ISSN: 0022-1767
GUICCIARDI MARIA EUGENIA ET AL: "Lysosomes in cell death.", ONCOGENE. 12 APR 2004, vol. 23, no. 16, 12 April 2004 (2004-04-12), pages 2881 - 2890, XP001205596, ISSN: 0950-9232
LIU NI ET AL: "Induction of a cathepsin B inhibitor by NF-kB blocks the lysosomal pathway of cell death.", FASEB JOURNAL, vol. 17, no. 7, 14 April 2003 (2003-04-14), & 90TH ANNIVERSARY ANNUAL MEETING OF THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS; DENVER, CO, USA; MAY 06-10, 2003, pages C152, XP009045219, ISSN: 0892-6638
LIU NI ET AL: "NF-kappaB protects from the lysosomal pathway of cell death.", EMBO (EUROPEAN MOLECULAR BIOLOGY ORGANIZATION) JOURNAL, vol. 22, no. 19, 1 October 2003 (2003-10-01), pages 5313 - 5322, XP001205586, ISSN: 0261-4189
BIRD P I: "Regulation of pro-apoptotic leucocyte granule serine proteinases by intracellular serpins.", IMMUNOLOGY AND CELL BIOLOGY. FEB 1999, vol. 77, no. 1, February 1999 (1999-02-01), pages 47 - 57, XP001205594, ISSN: 0818-9641
MORRIS EMMA C ET AL: "Nuclear localisation of haemopoietic serpin 2A: A potential regulatory of apoptosis", BRITISH JOURNAL OF HAEMATOLOGY, vol. 101, no. SUPPL. 1, May 1998 (1998-05-01), & ANNUAL SCIENTIFIC MEETING OF THE BRITISH SOCIETY FOR HAEMATOLOGY; GLASGOW, SCOTLAND, UK; APRIL 27-30, 1998, pages 27, XP009045220, ISSN: 0007-1048
HAMERMAN JESSICA A ET AL: "Serpin 2a is induced in activated macrophages and conjugates to a ubiquitin homolog", JOURNAL OF IMMUNOLOGY, vol. 168, no. 5, 1 March 2002 (2002-03-01), pages 2415 - 2423, XP009045212, ISSN: 0022-1767
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