Title:
METHODS AND COMPOSITIONS FOR INTERFERENCE WITH DNA POLYMERASE AND DNA SYNTHESIS
Document Type and Number:
WIPO Patent Application WO/2015/006641
Kind Code:
A3
Abstract:
Disclosed are methods and compositions for inhibiting DNA synthesis in a cell using RNA. Inhibition of DNA synthesis by RNA can be used, for example, in analytical methods, as a research tool to affect cells under study, to synchronize cell cycle in a cell culture, and to inhibit cell growth. For example, inhibition of DNA synthesis in cancer cells can be used to inhibit cancer cells and treat cancer. The RNA can be any RNA, such as whole cell RNA, whole cell mRNA, whole cell ribosomal RNA, whole cell transfer RNA, synthetic RNA, recombinant RNA, modified RNA, or a combination. The composition can comprise RNA and a pharmaceutically acceptable carrier or RNA, a targeting molecule, and a pharmaceutically acceptable carrier. The targeting molecule can be a tumor-targeting peptide.
Inventors:
HUANG ZHEN (US)
Application Number:
PCT/US2014/046275
Publication Date:
April 16, 2015
Filing Date:
July 11, 2014
Export Citation:
Assignee:
UNIV GEORGIA STATE RES FOUND (US)
International Classes:
C12N15/113
Other References:
L. V. GENING ET AL: "RNA aptamers selected against DNA polymerase inhibit the polymerase activities of DNA polymerases and", NUCLEIC ACIDS RESEARCH, vol. 34, no. 9, 17 May 2006 (2006-05-17), pages 2579 - 2586, XP055143809, ISSN: 0305-1048, DOI: 10.1093/nar/gkl326
LAKHIN ANDREI V ET AL: "Isolation and Characterization of High Affinity Aptamers Against DNA Polymerase Iota", NUCLEIC ACID THERAPEUTICS, vol. 22, no. 1, February 2012 (2012-02-01), pages 49 - 57, XP002730590, DOI: 10.1089/NAT.2011.0324
MARK E. DAVIS: "The First Targeted Delivery of siRNA in Humans via a Self-Assembling, Cyclodextrin Polymer-Based Nanoparticle: From Concept to Clinic", MOLECULAR PHARMACEUTICS, vol. 6, no. 3, 1 June 2009 (2009-06-01), pages 659 - 668, XP055144106, ISSN: 1543-8384, DOI: 10.1021/mp900015y
LINDA A. LANDON ET AL: "Combinatorial discovery of tumor targeting peptides using phage display", JOURNAL OF CELLULAR BIOCHEMISTRY, vol. 90, no. 3, 15 October 2003 (2003-10-15), pages 509 - 517, XP055008722, ISSN: 0730-2312, DOI: 10.1002/jcb.10634
LAKHIN ANDREI V ET AL: "Isolation and Characterization of High Affinity Aptamers Against DNA Polymerase Iota", NUCLEIC ACID THERAPEUTICS, vol. 22, no. 1, February 2012 (2012-02-01), pages 49 - 57, XP002730590, DOI: 10.1089/NAT.2011.0324
MARK E. DAVIS: "The First Targeted Delivery of siRNA in Humans via a Self-Assembling, Cyclodextrin Polymer-Based Nanoparticle: From Concept to Clinic", MOLECULAR PHARMACEUTICS, vol. 6, no. 3, 1 June 2009 (2009-06-01), pages 659 - 668, XP055144106, ISSN: 1543-8384, DOI: 10.1021/mp900015y
LINDA A. LANDON ET AL: "Combinatorial discovery of tumor targeting peptides using phage display", JOURNAL OF CELLULAR BIOCHEMISTRY, vol. 90, no. 3, 15 October 2003 (2003-10-15), pages 509 - 517, XP055008722, ISSN: 0730-2312, DOI: 10.1002/jcb.10634
Attorney, Agent or Firm:
HODGES, Robert, A. et al. (1545 Peachtree Street NE,Suite 32, Atlanta Georgia, US)
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