Title:
METHODS AND COMPOSITIONS FOR THE INTRAVENOUS ADMINISTRATION OF FUMARATES FOR THE TREATMENT OF NEUROLOGICAL DISEASES
Document Type and Number:
WIPO Patent Application WO/2016/153957
Kind Code:
A3
Abstract:
Disclosed herein are methods and compositions for the intravenous administration of fumarates for the treatment of neurological diseases, such as stroke, amyotrophic lateral sclerosis, Huntington's disease, Alzheimer's disease, Parkinson's disease, and Multiple Sclerosis.
Inventors:
VERMA AJAY (US)
SCANNEVIN ROBERT (US)
KARKI SHYAM (US)
ZHENG FENGMEI (US)
SCANNEVIN ROBERT (US)
KARKI SHYAM (US)
ZHENG FENGMEI (US)
Application Number:
PCT/US2016/023021
Publication Date:
November 10, 2016
Filing Date:
March 18, 2016
Export Citation:
Assignee:
BIOGEN MA INC (US)
International Classes:
A61K31/225; A61K9/10; A61K31/365; A61K31/5375; A61K31/54; A61K31/661; A61K31/695; A61K47/40; A61P9/10; A61P25/00; A61P25/16; A61P25/28
Domestic Patent References:
| WO2016074684A1 | 2016-05-19 | |||
| WO2013119677A1 | 2013-08-15 | |||
| WO2013090799A1 | 2013-06-20 | |||
| WO2008096271A2 | 2008-08-14 | |||
| WO2005023241A1 | 2005-03-17 | |||
| WO2006037342A2 | 2006-04-13 |
Foreign References:
| CN103768045A | 2014-05-07 | |||
| US20140179779A1 | 2014-06-26 | |||
| US20150079180A1 | 2015-03-19 |
Other References:
TAE GEN SON ET AL: "Plumbagin, a novel Nrf2/ARE activator, protects against cerebral ischemia", JOURNAL OF NEUROCHEMISTRY, vol. 112, no. 5, March 2010 (2010-03-01), NEW YORK, NY, US, pages 1316 - 1326, XP055276327, ISSN: 0022-3042, DOI: 10.1111/j.1471-4159.2009.06552.x
GISA ELLRICHMANN ET AL: "Efficacy of Fumaric Acid Esters in the R6/2 and YAC128 Models of Huntington's Disease", PLOS ONE, vol. 6, no. 1, 31 January 2011 (2011-01-31), pages e16172, XP055301151, DOI: 10.1371/journal.pone.0016172
JING X ET AL: "Dimethyl fumarate attenuates 6-OHDA-induced neurotoxicity in SH-SY5Y cells and in animal model of Parkinson's disease by enhancing Nrf2 acti", NEUROSCIENCE, vol. 286, 29 November 2014 (2014-11-29), pages 131 - 140, XP029188354, ISSN: 0306-4522, DOI: 10.1016/J.NEUROSCIENCE.2014.11.047
L YANG ET AL: "Neuroprotective effects of fumarates against MPTP mouse model of Parkinson's disease", SOCIETY FOR NEUROSCIENCE, vol. 43, November 2013 (2013-11-01), XP055301652
ANONYMOUS: "Hydroxypropylbetacyclodextrin", June 2009 (2009-06-01), pages 36 - 39, XP055303673, Retrieved from the Internet [retrieved on 20160919]
ANONYMOUS: "Ligand: Effective Drug Delivery Solutions With Captisol", DRUG DEVELOPMENT & DELIVERY, vol. 13, no. 8, October 2013 (2013-10-01), pages 64 - 66, XP055303766
GISA ELLRICHMANN ET AL: "Efficacy of Fumaric Acid Esters in the R6/2 and YAC128 Models of Huntington's Disease", PLOS ONE, vol. 6, no. 1, 31 January 2011 (2011-01-31), pages e16172, XP055301151, DOI: 10.1371/journal.pone.0016172
JING X ET AL: "Dimethyl fumarate attenuates 6-OHDA-induced neurotoxicity in SH-SY5Y cells and in animal model of Parkinson's disease by enhancing Nrf2 acti", NEUROSCIENCE, vol. 286, 29 November 2014 (2014-11-29), pages 131 - 140, XP029188354, ISSN: 0306-4522, DOI: 10.1016/J.NEUROSCIENCE.2014.11.047
L YANG ET AL: "Neuroprotective effects of fumarates against MPTP mouse model of Parkinson's disease", SOCIETY FOR NEUROSCIENCE, vol. 43, November 2013 (2013-11-01), XP055301652
ANONYMOUS: "Hydroxypropylbetacyclodextrin", June 2009 (2009-06-01), pages 36 - 39, XP055303673, Retrieved from the Internet
ANONYMOUS: "Ligand: Effective Drug Delivery Solutions With Captisol", DRUG DEVELOPMENT & DELIVERY, vol. 13, no. 8, October 2013 (2013-10-01), pages 64 - 66, XP055303766
Attorney, Agent or Firm:
ANTLER, Adriane, M. et al. (250 Vesey StreetNew York, NY, US)
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