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Title:
METHODS, COMPOSITIONS AND KITS RELATING TO CHITINASES AND CHITINASE-LIKE MOLECULES AND INFLAMMATORY DISEASE
Document Type and Number:
WIPO Patent Application WO2003009808
Kind Code:
A3
Abstract:
The present invention includes compositions and methods for the treatment of inflammatory disease (e.g., asthma, COPD, inflammatory bowel disease, atopic dermatitis, allergy, allergic rhinitis, scleroderma, and the like), relating to inhibiting a chitinase-like molecule. The invention further includes methods to identify new compounds for the treatment of the inflammatory disease, including, but not limited to, asthma, COPD and the like. This is because the present invention demonstrates, for the first time, that expression of IL-13, and of a chitinase-like molecule, mediates and/or is associated with inflammatory disease and that inhibiting the chitinase-like molecule treats and even prevents, the disease. Thus, the invention relates to the novel discovery that inhibiting a chitinase-like molecule treats and prevents an inflammatory disease.

Inventors:
ELIAS JACK A (US)
ZHU ZHOU (US)
Application Number:
US0223516W
Publication Date:
September 04, 2003
Filing Date:
July 23, 2002
Export Citation:
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Assignee:
YALE UNIVERSITY
ELIAS, JACK, A.
ZHU, ZHOU
International Classes:
A61K31/00; A61K31/70; A61K38/12; A61P11/00; A61P11/06; A61P29/00; A61P37/08; C07K16/40; C12N9/24; C12N15/24; A61K38/00; (IPC1-7): A01N61/00; A01N43/60; A61K51/00; C07H19/207
Domestic Patent References:
WO1994028889A11994-12-22
Other References:
See also references of EP 1418813A4
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