Title:
METHODS AND COMPOSITIONS FOR LIMITING VIABILITY OF A MODIFIED HOST CELL OUTSIDE OF DESIGNATED PROCESS CONDITIONS
Document Type and Number:
WIPO Patent Application WO/2012/040361
Kind Code:
A3
Abstract:
The invention provides methods and compositions for inhibiting proliferation of a modified host cell outside of a designated process condition. Compositions and methods for providing a host cell having reduced viability when exposed to natural conditions external to a controlled environment are disclosed.
Inventors:
CHURCH GEORGE (US)
SKRALY FRANK ANTHONY (US)
GREEN BRIAN D (US)
HARRISON JACOB CARTER (US)
SKRALY FRANK ANTHONY (US)
GREEN BRIAN D (US)
HARRISON JACOB CARTER (US)
Application Number:
PCT/US2011/052606
Publication Date:
March 27, 2014
Filing Date:
September 21, 2011
Export Citation:
Assignee:
JOULE UNLTD TECHNOLOGIES INC (US)
CHURCH GEORGE (US)
SKRALY FRANK ANTHONY (US)
GREEN BRIAN D (US)
HARRISON JACOB CARTER (US)
CHURCH GEORGE (US)
SKRALY FRANK ANTHONY (US)
GREEN BRIAN D (US)
HARRISON JACOB CARTER (US)
International Classes:
C12N1/12; C12N1/20
Foreign References:
| US7183097B1 | 2007-02-27 |
Other References:
OGAWA.: "A gene homologous to the subunit-2 gene of NADH dehydrogenase is essential to inorganic carbon transport of Synechocystis PCC6803.", PROC NAT ACAD SCI, vol. 88, no. 10, 1991, pages 4275 - 4279
HITOMI ET AL.: "Bacterial cryptochrome and photolyase: characterization of two photolyase-like genes of Synechocystis sp. PCC6803.", NUCL ACIDS RES, vol. 28, no. 12, 2000, pages 2353 - 2362
MELNIKOV ET AL.: "Site-specific recombination in the cyanobacterium Anabaena sp. strain PCC 7120 catalyzed by the integrase of coliphage HK022.", J BACTERIOL, vol. 191, no. 13, 2009, pages 4458 - 4464
J CRAIG VENTER INSTITUTE.: "Synechococcus elongatus PCC 7942 Genome", 18 April 2006 (2006-04-18), pages 1, Retrieved from the Internet [retrieved on 20120320]
WILLIAMS ET AL.: "Stable integration of foreign DNA into the chromosome of the cyanobacterium Synechococcus R2.", GENE, vol. 24, no. 1, 1983, pages 37 - 51, XP023539522, DOI: doi:10.1016/0378-1119(83)90129-4
HITOMI ET AL.: "Bacterial cryptochrome and photolyase: characterization of two photolyase-like genes of Synechocystis sp. PCC6803.", NUCL ACIDS RES, vol. 28, no. 12, 2000, pages 2353 - 2362
MELNIKOV ET AL.: "Site-specific recombination in the cyanobacterium Anabaena sp. strain PCC 7120 catalyzed by the integrase of coliphage HK022.", J BACTERIOL, vol. 191, no. 13, 2009, pages 4458 - 4464
J CRAIG VENTER INSTITUTE.: "Synechococcus elongatus PCC 7942 Genome", 18 April 2006 (2006-04-18), pages 1, Retrieved from the Internet
WILLIAMS ET AL.: "Stable integration of foreign DNA into the chromosome of the cyanobacterium Synechococcus R2.", GENE, vol. 24, no. 1, 1983, pages 37 - 51, XP023539522, DOI: doi:10.1016/0378-1119(83)90129-4
Attorney, Agent or Firm:
HURT, Nicholas, S. et al. (Silicon Valley Center801 California Stree, Mountain View CA, US)
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