Title:
METHODS AND COMPOSITIONS FOR MITIGATING PAIN USING NITRATE ESTERS
Document Type and Number:
WIPO Patent Application WO2001049275
Kind Code:
A3
Abstract:
Methods and therapeutic compounds for treating pain, mitigating inflammation, effecting analgesia and/or effecting sedation in a subject are described. A subject is administered an effective amount of a therapeutic compound which is a nitrate ester. Novel pharmaceutical compositions are also described.
Inventors:
THATCHER GREGORY R J (CA)
BENNETT BRIAN M (CA)
REYNOLDS JAMES N (CA)
JHAMANDAS KHEM (CA)
BENNETT BRIAN M (CA)
REYNOLDS JAMES N (CA)
JHAMANDAS KHEM (CA)
Application Number:
PCT/CA2000/001523
Publication Date:
December 13, 2001
Filing Date:
December 27, 2000
Export Citation:
Assignee:
UNIV KINGSTON (CA)
THATCHER GREGORY R J (CA)
BENNETT BRIAN M (CA)
REYNOLDS JAMES N (CA)
JHAMANDAS KHEM (CA)
THATCHER GREGORY R J (CA)
BENNETT BRIAN M (CA)
REYNOLDS JAMES N (CA)
JHAMANDAS KHEM (CA)
International Classes:
A61K31/00; A61K31/04; A61K31/21; A61K31/216; A61K31/223; A61K31/235; A61K31/24; A61K31/255; A61K31/26; A61K31/265; A61K31/275; C07D295/12; A61K31/36; A61K31/37; A61K31/38; A61K31/381; A61K31/385; A61K31/39; A61K31/40; A61K31/401; A61K31/404; A61K31/407; A61K31/415; A61K31/416; A61K31/425; A61K31/426; A61K31/47; A61K31/495; A61K31/506; A61K31/522; A61K31/5375; A61K31/575; A61K31/662; A61K38/00; A61P23/00; A61P25/04; A61P25/20; A61P25/22; A61P29/00; C07C203/04; C07C203/06; C07C205/40; C07C309/12; C07C317/18; C07C323/12; C07C323/20; C07C323/58; C07C323/62; C07C327/28; C07C331/10; C07D207/16; C07D207/337; C07D209/26; C07D215/36; C07D231/12; C07D277/24; C07D277/28; C07D295/088; C07D307/33; C07D311/16; C07D311/18; C07D317/60; C07D327/04; C07D331/02; C07D333/42; C07D333/44; C07D333/48; C07D339/08; C07D409/04; C07D411/04; C07D473/04; C07D473/08; C07D487/04; C07D491/04; C07D491/052; C07F9/38; C07F9/40; C07J9/00; C07J41/00; C07D207/32; (IPC1-7): A61K31/662; A61K31/426; A61K31/40; A61P29/00; A61P25/20; A61P25/22; A61P23/00; A61K31/21; A61K31/24; A61K31/265; A61K31/425
Domestic Patent References:
| WO1995030641A1 | 1995-11-16 | |||
| WO1998025918A1 | 1998-06-18 | |||
| WO1997046521A1 | 1997-12-11 | |||
| WO2000054756A2 | 2000-09-21 |
Foreign References:
| US5693676A | 1997-12-02 | |||
| US3869451A | 1975-03-04 | |||
| EP0664127A2 | 1995-07-26 |
Other References:
XU JIMMY YU ET AL: "Activation of a NO-cyclic GMP system by NO donors potentiates beta-endorphin-induced antinociception in the mouse.", PAIN, vol. 63, no. 3, 1995, pages 377 - 383, XP001004459, ISSN: 0304-3959
S. H. FERREIRA: "Inflammatory pain: the role of cytokines and its control by drugs which release nitric oxide.", ANNALI DELL'ISTITUTO SUPERIORE DI SANITÀ, vol. 29, no. 3, 1993, pages 367 - 373, XP001004461
YANG K ET AL: "SYNTHESIS OF NOVEL ORGANIC NITRATE ESTERS: GUANYLATE CYCLASE ACTIVATION AND TISSUE RELAXATION", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1, CHEMICAL SOCIETY. LETCHWORTH, GB, no. 11, 1996, pages 1073 - 1075, XP002039309, ISSN: 1472-7781
GOLDING P., MILLAR R., PAUL C., RICHARDS D.: "Nitration by oxides of nitrogen. Part 6. Preparation of di- and polynitrates by ring-opening nitration of epoxides by dinitrogen pentoxide (N2O5)", TETRAHEDRON, vol. 49, no. 32, 1993, pages 7037 - 7050, XP001016266
BURKE D H ET AL: "SODIUM NITROPRUSSIDE INDUCED HYPO THERMIA IN MICE", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 66, no. 11, 1977, EN, pages 1658 - 1660, XP001025601, ISSN: 0022-3549
REYNOLDS J N ET AL: "Cognition enhancement and sedative-hypnotic properties with a novel nitrate ester.", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 26, no. 1-2, 2000, 30th Annual Meeting of the Society of Neuroscience;New Orleans, LA, USA; November 04-09, 2000, pages Abstract No. - 653.9, XP001025586, ISSN: 0190-5295
S. H. FERREIRA: "Inflammatory pain: the role of cytokines and its control by drugs which release nitric oxide.", ANNALI DELL'ISTITUTO SUPERIORE DI SANITÀ, vol. 29, no. 3, 1993, pages 367 - 373, XP001004461
YANG K ET AL: "SYNTHESIS OF NOVEL ORGANIC NITRATE ESTERS: GUANYLATE CYCLASE ACTIVATION AND TISSUE RELAXATION", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1, CHEMICAL SOCIETY. LETCHWORTH, GB, no. 11, 1996, pages 1073 - 1075, XP002039309, ISSN: 1472-7781
GOLDING P., MILLAR R., PAUL C., RICHARDS D.: "Nitration by oxides of nitrogen. Part 6. Preparation of di- and polynitrates by ring-opening nitration of epoxides by dinitrogen pentoxide (N2O5)", TETRAHEDRON, vol. 49, no. 32, 1993, pages 7037 - 7050, XP001016266
BURKE D H ET AL: "SODIUM NITROPRUSSIDE INDUCED HYPO THERMIA IN MICE", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 66, no. 11, 1977, EN, pages 1658 - 1660, XP001025601, ISSN: 0022-3549
REYNOLDS J N ET AL: "Cognition enhancement and sedative-hypnotic properties with a novel nitrate ester.", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 26, no. 1-2, 2000, 30th Annual Meeting of the Society of Neuroscience;New Orleans, LA, USA; November 04-09, 2000, pages Abstract No. - 653.9, XP001025586, ISSN: 0190-5295
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