Title:
METHODS AND COMPOSITIONS FOR MODULATING APOPTOSIS
Document Type and Number:
WIPO Patent Application WO2003028659
Kind Code:
A3
Abstract:
Methods and compositions for modulating apoptosis by acting on the c-Jun-N-terminal kinase (JNK) pathway. Assays for the isolation of agents capable of modulating apoptosis, including modulators of the JNK pathway. A member of the Gadd45 protein family that inhibits JNK signaling is a target. Methods and compositions are presented for the preparation and use of novel therapeutic compositions for modulating diseases and conditions associated with elevated or decreased apoptosis.
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Inventors:
FRANZOSO GUIDO (US)
DE SMAELE ENRICO (IT)
ZAZZERONI FRANCESCA (US)
PAPA SALVATORE (US)
DE SMAELE ENRICO (IT)
ZAZZERONI FRANCESCA (US)
PAPA SALVATORE (US)
Application Number:
PCT/US2002/031548
Publication Date:
May 27, 2004
Filing Date:
October 02, 2002
Export Citation:
Assignee:
UNIV CHICAGO (US)
FRANZOSO GUIDO (US)
DE SMAELE ENRICO (IT)
ZAZZERONI FRANCESCA (US)
PAPA SALVATORE (US)
FRANZOSO GUIDO (US)
DE SMAELE ENRICO (IT)
ZAZZERONI FRANCESCA (US)
PAPA SALVATORE (US)
International Classes:
A61K31/00; C07K14/47; C12N9/12; A61K38/00; (IPC1-7): C12Q1/68; C07H21/00
Foreign References:
| US5866332A | 1999-02-02 |
Other References:
WANG X. W. ET AL: "GADD45 induction of a G2/M cell cycle checkpoint", PROC. NATL. ACAD. SCI., vol. 96, no. 7, March 1999 (1999-03-01), pages 3706 - 3711, XP002979859
LIEBERMANN D. A. ET AL: "MyDD118/Gadd445/CR6 in blood cell homeostasis", BLOOD, vol. 96, no. 11, PART 2., 16 November 2000 (2000-11-16), pages 146B, XP002979871
MITA H. ET AL: "Regulation of MTK1/MEKKA kinase activity by its N-terminal autoinhibitory domain and GADD45 binding", MOLECULAR AND CELLULAR BIOLOGY, vol. 22, no. 13, July 2002 (2002-07-01), pages 4544 - 4555, XP002979861
DE SMAELE ET AL: "Induction of GADD45B by NF-kB down regulates pro-apoptotic JNK signalling", NATURE, vol. 414, 15 November 2001 (2001-11-15), pages 308 - 313, XP002979860
TAKEKAWA ET AL: "A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1MEKKA MAPKKK", CELL, vol. 95, no. 4, 13 November 1998 (1998-11-13), pages 521 - 530, XP002979862
JIN ET AL: "Regulation of the GADD45B promoter by NF-kB", DNA AND CELL BIOLOGY, vol. 21, no. 7, July 2002 (2002-07-01), pages 491 - 503, XP002979863
WANG ET AL: "GADD45 is not required for activation of cJUN N-terminal kinase of p38 during acute stress", THE JOURNAL OF BIOLOGY CHEMISTRY, vol. 274, no. 42, 15 October 1999 (1999-10-15), pages 29599 - 29602, XP002979864
LIEBERMANN D. A. ET AL: "MyDD118/Gadd445/CR6 in blood cell homeostasis", BLOOD, vol. 96, no. 11, PART 2., 16 November 2000 (2000-11-16), pages 146B, XP002979871
MITA H. ET AL: "Regulation of MTK1/MEKKA kinase activity by its N-terminal autoinhibitory domain and GADD45 binding", MOLECULAR AND CELLULAR BIOLOGY, vol. 22, no. 13, July 2002 (2002-07-01), pages 4544 - 4555, XP002979861
DE SMAELE ET AL: "Induction of GADD45B by NF-kB down regulates pro-apoptotic JNK signalling", NATURE, vol. 414, 15 November 2001 (2001-11-15), pages 308 - 313, XP002979860
TAKEKAWA ET AL: "A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1MEKKA MAPKKK", CELL, vol. 95, no. 4, 13 November 1998 (1998-11-13), pages 521 - 530, XP002979862
JIN ET AL: "Regulation of the GADD45B promoter by NF-kB", DNA AND CELL BIOLOGY, vol. 21, no. 7, July 2002 (2002-07-01), pages 491 - 503, XP002979863
WANG ET AL: "GADD45 is not required for activation of cJUN N-terminal kinase of p38 during acute stress", THE JOURNAL OF BIOLOGY CHEMISTRY, vol. 274, no. 42, 15 October 1999 (1999-10-15), pages 29599 - 29602, XP002979864
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