Title:
METHODS AND COMPOSITIONS FOR THE PROGNOSIS AND TREATMENT OF RELAPSED LEUKEMIA
Document Type and Number:
WIPO Patent Application WO/2013/169771
Kind Code:
A3
Abstract:
The present invention is directed to methods of prognosing relapsed leukemia in a subject. These methods are based on the detection of one or more relapse-specific gene mutations in a patient sample. The present invention further relates to methods of preventing and treating relapse leukemia in a subject based on the determined prognosis of the subject.
Inventors:
CARROLL WILLIAM L (US)
MEYER JULIA A (US)
MEYER JULIA A (US)
Application Number:
PCT/US2013/039942
Publication Date:
April 03, 2014
Filing Date:
May 07, 2013
Export Citation:
Assignee:
UNIV NEW YORK (US)
CARROLL WILLIAM L (US)
MEYER JULIA A (US)
CARROLL WILLIAM L (US)
MEYER JULIA A (US)
International Classes:
C12Q1/68
Domestic Patent References:
| WO2010138843A2 | 2010-12-02 |
Foreign References:
| US20120072124A1 | 2012-03-22 |
Other References:
MITRA ET AL.: "A Genetic Variants in Cytosolic 5'-Nucleotidase II Are Associated with Its Expression and Cytarabine Sensitivity in HapMap Cell Lines and in Patients with Acute Myeloid Leukemia", THE JOUMAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 339, no. 1, 28 June 2011 (2011-06-28), pages 9 - 23
GALMARINI ET AL.: "Nucleoside analogues and nucleobases in cancer treatment", THE LANCET ONCOLOGY, vol. 3, no. 7, 31 July 2002 (2002-07-31), pages 415 - 424
GALMARINI ET AL.: "Nucleoside analogues and nucleobases in cancer treatment", THE LANCET ONCOLOGY, vol. 3, no. 7, 31 July 2002 (2002-07-31), pages 415 - 424
Attorney, Agent or Firm:
CHILDS, Carissa, R. et al. (70 Linden OaksSuite 21, Rochester NY, US)
Download PDF: