Title:
METHODS AND COMPOSITIONS FOR REDUCING ALCOHOL TOXICITY
Document Type and Number:
WIPO Patent Application WO/2013/078371
Kind Code:
A3
Abstract:
The present invention comprises methods and compositions for reducing ethanol toxicity due to accumulation of acetaldehyde in a cell. A method comprises administering to a cell a composition comprising a compound that increases the expression, the amount of, and/or the activity of at least one member of the aldehyde dehydrogenase superfamily.
Inventors:
TALALAY PAUL (US)
USHIDA YUSUKE (US)
USHIDA YUSUKE (US)
Application Number:
PCT/US2012/066340
Publication Date:
December 04, 2014
Filing Date:
November 21, 2012
Export Citation:
Assignee:
UNIV JOHNS HOPKINS (US)
International Classes:
C07K1/00
Foreign References:
| US20110065659A1 | 2011-03-17 | |||
| US20050271754A1 | 2005-12-08 | |||
| US20080311276A1 | 2008-12-18 |
Other References:
THIMMULAPPA ET AL.: "Identification of Nrf2-regulated Genes Induced by the Chemopreventive Agent Sulforaphane by Oligonucleotide Microarray", CANCER RESEARCH, vol. 62, 15 September 2002 (2002-09-15), pages 5196 - 5203, XP002471401
HEAVEY ET AL.: "Colorectal Cancer and the Relationship Between Genes and the Environment", NUTRITION AND CANCER, vol. 48, no. 2, 2004, pages 124 - 141, XP008174354
HEAVEY ET AL.: "Colorectal Cancer and the Relationship Between Genes and the Environment", NUTRITION AND CANCER, vol. 48, no. 2, 2004, pages 124 - 141, XP008174354
Attorney, Agent or Firm:
MCFADYEN, Rebecca, C.E. et al. (LLP999 Peachtree Street,Suite 100, Atlanta GA, US)
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