Title:
METHODS AND COMPOSITIONS FOR REDUCING SERUM LEVELS OF IMMUNOGLOBULIN E (IGE)
Document Type and Number:
WIPO Patent Application WO/2013/033155
Kind Code:
A8
Abstract:
The present disclosure provides methods and pharmaceutical compositions for reducing the serum level of immunoglobulin IgE in an animal or human subject. It has been found that reducing or inhibiting the activity of the cannabinoid receptor CB2 leads to an increase in IgE in serum levels. Conversely, activation of the CB2 receptor by an agonist results in a reduction in IgE serum levels. The compositions and methods of the disclosure, therefore, provide a means to reduce or eliminate symptoms of immune system-related conditions resulting from IgE generation, such as an allergy, hay fever, and the like.
Inventors:
KLEIN THOMAS W (US)
NEWTON CATHERINE (US)
PATTERSON CATHERINE (US)
AGUDELO MARISELA (US)
NEWTON CATHERINE (US)
PATTERSON CATHERINE (US)
AGUDELO MARISELA (US)
Application Number:
PCT/US2012/052787
Publication Date:
April 04, 2013
Filing Date:
August 29, 2012
Export Citation:
Assignee:
UNIV SOUTH FLORIDA (US)
KLEIN THOMAS W (US)
NEWTON CATHERINE (US)
PATTERSON CATHERINE (US)
AGUDELO MARISELA (US)
KLEIN THOMAS W (US)
NEWTON CATHERINE (US)
PATTERSON CATHERINE (US)
AGUDELO MARISELA (US)
International Classes:
A61K31/416; A61K31/41; A61K31/415; A61P37/00
Attorney, Agent or Firm:
HAYZER, David, J. (Suite 1500Atlanta, GA, US)
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