Title:
METHODS AND COMPOSITIONS FOR REDUCING UV-INDUCED INHIBITION OF COLLAGEN SYNTHESIS IN HUMAN SKIN
Document Type and Number:
WIPO Patent Application WO1999051220
Kind Code:
A9
Abstract:
Exposure of human skin to ultraviolet (UV) radiation from the sun not only induces the production of enzymes (matrix metalloproteinases) that degrade collagen, but also inhibits the synthesis of new collagen by inhibiting the synthesis of procollagen. This UV-induced inhibition of the synthesis of collagen can be prevented by the topical application of a retinoid or c-JUN inhibitor to the skin prior to its exposure to UV radiation.
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Inventors:
FISHER GARY J
VOORHEES JOHN J
VOORHEES JOHN J
Application Number:
PCT/US1999/007267
Publication Date:
April 27, 2000
Filing Date:
April 02, 1999
Export Citation:
Assignee:
UNIV MICHIGAN (US)
International Classes:
A61K8/35; A61K8/37; A61K8/67; A61K31/07; A61K31/165; A61K31/167; A61K31/17; A61K31/185; A61K31/196; A61K31/203; A61K31/235; A61K31/277; A61K31/35; A61K31/352; A61K31/4439; A61K31/517; A61K31/522; A61K45/06; A61P17/02; A61P43/00; A61Q17/04; A61Q19/08; (IPC1-7): A61K31/20; A61K31/12; A61K31/17; A61K31/235; A61K31/35
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