METHODS AND COMPOSITIONS RELATED TO T-CELL ACTIVITY

Title:

METHODS AND COMPOSITIONS RELATED TO T-CELL ACTIVITY

Document Type and Number:

WIPO Patent Application WO/2014/144666

Kind Code:

A3

Abstract:

Embodiments concern methods and composition related to anergic T-cells in patients, such as cancer patients. T cell anergy is a hyporesponsive state induced by TCR engagement in the absence of costimulation (Schwartz, 2003). Anergy induction was initially observed in vitro using chemically-fixed antigen presenting cells (APCs). Subsequently, it was found that anergy could be induced by immobilized anti-CD3 mAb or calcium ionophores (such as ionomycin) in vitro, and by superantigen and soluble antigenic peptide in vivo. Indirect evidence has suggested that T cell dysfunction in the tumor microenvironment and establishment of transplant tolerance is partially due to T cell anergy (Gajewski et al., 2011 ).

Inventors:

ZHENG YAN (US)
ZHA YUANYUAN (US)
SPAAPEN ROBERT M (US)
GAJEWSKI THOMAS F (US)

Application Number:

PCT/US2014/029173

Publication Date:

December 18, 2014

Filing Date:

March 14, 2014

Export Citation:

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Assignee:

UNIV CHICAGO (US)

International Classes:

C12N5/0783

Domestic Patent References:

WO2004050706A2	2004-06-17
WO2003074654A2	2003-09-12
WO2012178160A2	2012-12-27

Foreign References:

US20120135014A1

2012-05-31

Other References: