Title:
METHODS AND COMPOSITIONS RELATING TO ALZHEIMER'S DISEASE
Document Type and Number:
WIPO Patent Application WO2006035237
Kind Code:
A3
Abstract:
Methods and compositions relating to Alzheimer's disease are provided. Specifically, proteins that are differentially expressed in the Alzheimer's disease state relative to their expression in the normal state are provided. Proteins associated with Alzheimer's disease are identified and described. Methods of diagnosis of Alzheimer's disease using the differentially expressed proteins are also provided, as are methods for the identification and therapeutic use of compounds for the prevention and treatment of Alzheimer's disease.
Inventors:
WESTBROOK JULES (GB)
BYERS HELEN (GB)
WARD MALCOLM (GB)
LOVESTONE SIMON (GB)
HYE ABDUL (GB)
LYNHAM STEVEN (GB)
JOUBERT RICHARD (DE)
PREFOT PETRA (DE)
KUHN KARSTEN (DE)
BAUMANN CHRISTIAN (DE)
SCHAEFER JUERGEN (DE)
PRINZ THORSTEN (DE)
KIENLE STEFAN (DE)
BYERS HELEN (GB)
WARD MALCOLM (GB)
LOVESTONE SIMON (GB)
HYE ABDUL (GB)
LYNHAM STEVEN (GB)
JOUBERT RICHARD (DE)
PREFOT PETRA (DE)
KUHN KARSTEN (DE)
BAUMANN CHRISTIAN (DE)
SCHAEFER JUERGEN (DE)
PRINZ THORSTEN (DE)
KIENLE STEFAN (DE)
Application Number:
PCT/GB2005/003756
Publication Date:
August 03, 2006
Filing Date:
September 29, 2005
Export Citation:
Assignee:
PROTEOME SCIENCES PLC (GB)
KING S COLLEGE LONDON (GB)
WESTBROOK JULES (GB)
BYERS HELEN (GB)
WARD MALCOLM (GB)
LOVESTONE SIMON (GB)
HYE ABDUL (GB)
LYNHAM STEVEN (GB)
JOUBERT RICHARD (DE)
PREFOT PETRA (DE)
KUHN KARSTEN (DE)
BAUMANN CHRISTIAN (DE)
SCHAEFER JUERGEN (DE)
PRINZ THORSTEN (DE)
KIENLE STEFAN (DE)
KING S COLLEGE LONDON (GB)
WESTBROOK JULES (GB)
BYERS HELEN (GB)
WARD MALCOLM (GB)
LOVESTONE SIMON (GB)
HYE ABDUL (GB)
LYNHAM STEVEN (GB)
JOUBERT RICHARD (DE)
PREFOT PETRA (DE)
KUHN KARSTEN (DE)
BAUMANN CHRISTIAN (DE)
SCHAEFER JUERGEN (DE)
PRINZ THORSTEN (DE)
KIENLE STEFAN (DE)
International Classes:
A61P25/28; G01N33/68
Foreign References:
| US20030211622A1 | 2003-11-13 | |||
| US20030131364A1 | 2003-07-10 | |||
| US20020174447A1 | 2002-11-21 |
Other References:
TILLEMAN KELLY ET AL: "Differential expression of brain proteins in glycogen synthase kinase-3beta transgenic mice: A proteomics point of view", PROTEOMICS, vol. 2, no. 1, January 2002 (2002-01-01), pages 94 - 104, XP009063196, ISSN: 1615-9853
ANDREASEN NIELS ET AL: "Cerebrospinal fluid beta-amyloid(1-42) in Alzheimer disease: Differences between early- and late-onset Alzheimer disease and stability during the course of disease", ARCHIVES OF NEUROLOGY, vol. 56, no. 6, June 1999 (1999-06-01), pages 673 - 680, XP009063181, ISSN: 0003-9942
KANAI ET AL: "LONGITUDINAL STUDY OF CEREBROSPINAL FLUID LEVELS OF TAU, ABETA-40, AND ABETA1-42(43) IN ALZHEIMER'S DISEASE: A STUDY IN JAPAN", ANNALS OF NEUROLOGY, BOSTON, US, vol. 44, no. 1, July 1998 (1998-07-01), pages 17 - 26, XP000827916, ISSN: 0364-5134
ANDREASEN NIELS ET AL: "Cerebrospinal fluid beta-amyloid(1-42) in Alzheimer disease: Differences between early- and late-onset Alzheimer disease and stability during the course of disease", ARCHIVES OF NEUROLOGY, vol. 56, no. 6, June 1999 (1999-06-01), pages 673 - 680, XP009063181, ISSN: 0003-9942
KANAI ET AL: "LONGITUDINAL STUDY OF CEREBROSPINAL FLUID LEVELS OF TAU, ABETA-40, AND ABETA1-42(43) IN ALZHEIMER'S DISEASE: A STUDY IN JAPAN", ANNALS OF NEUROLOGY, BOSTON, US, vol. 44, no. 1, July 1998 (1998-07-01), pages 17 - 26, XP000827916, ISSN: 0364-5134
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