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Patent Searching and Data


Title:
METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF ANTITHROMBIN 3 (AT3) BY DOUBLE-STRANDED RNA
Document Type and Number:
WIPO Patent Application WO/2016/183009
Kind Code:
A3
Abstract:
This invention relates to compounds, compositions, and methods useful for reducing AT3 target RNA and protein levels via use of dsRNAs, e.g., Dicer substrate siRNA (DsiRNA) agents.

Inventors:
BROWN BOB D (US)
DUDEK HENRYK T (US)
Application Number:
PCT/US2016/031471
Publication Date:
February 16, 2017
Filing Date:
May 09, 2016
Export Citation:
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Assignee:
DICERNA PHARMACEUTICALS INC (US)
International Classes:
A61K31/7088; A61K31/713; A61P7/04; C07K14/81; C12N15/113
Foreign References:
US20130317081A12013-11-28
US20140315983A12014-10-23
US7691810B22010-04-06
Other References:
OMASA ET AL.: "Decrease in Antithrombin III Fucosylation by Expressing GDP-fucose Transporter siRNA in Chinese Hamster Ovary Cells", JOURNAL OF BIOSCIENCE AND BIOENGINEERING, vol. 106, no. 2, 17 September 2008 (2008-09-17), pages 168 - 172, XP025430495
SAFDAR ET AL.: "Acute and severe coagulopathy in adult mice following silencing of hepatic antithrombin and protein C production", BLOOD, vol. 121, no. 21, 23 May 2013 (2013-05-23), pages 4413 - 4416, XP055206525
Attorney, Agent or Firm:
COWLWS, Christopher, R. et al. (US)
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