METHODS AND COMPOSITIONS FOR THE SYNTHESIS OF MULTIMERIZING AGENTS

Title:

METHODS AND COMPOSITIONS FOR THE SYNTHESIS OF MULTIMERIZING AGENTS

Document Type and Number:

WIPO Patent Application WO/2012/103279

Kind Code:

A3

Abstract:

The invention features methods and compositions for the synthesis of multimerizing agents. An exemplary method for producing AP20187 may comprise: (a) coupling 2-N,Ndimethylaminomethyl-1,3-diaminopropane with AP20792 to produce the dimeric alcohol, AP20793; and (b) coupling the AP20793 so produced with API7362 to yield AP20187. In particular embodiments, the method further includes the step of producing API7362 by coupling API7360 with methyl-L-pipecolic acid, or a salt thereof.

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Inventors:

LI FENG (US)
WANG YIHAN (US)

Application Number:

PCT/US2012/022642

Publication Date:

September 20, 2012

Filing Date:

January 26, 2012

Export Citation:

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Assignee:

ARIAD PHARMA INC (US)
LI FENG (US)
WANG YIHAN (US)

International Classes:

C07D319/06

Foreign References:

US5580993A	1996-12-03
US6417403B1	2002-07-09

Other References:

ANNENKOV ET AL.: "Synthesis of Biomimetic Polyamines.", ARKIVOC, vol. XIII, 2009, pages 116 - 130

Attorney, Agent or Firm:

ELLISON, Jeffrey J. (101 Federal StreetBoston, MA, US)

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