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Patent Searching and Data


Title:
METHODS AND COMPOSITIONS FOR THE SYNTHESIS OF MULTIMERIZING AGENTS
Document Type and Number:
WIPO Patent Application WO/2012/103279
Kind Code:
A3
Abstract:
The invention features methods and compositions for the synthesis of multimerizing agents. An exemplary method for producing AP20187 may comprise: (a) coupling 2-N,Ndimethylaminomethyl-1,3-diaminopropane with AP20792 to produce the dimeric alcohol, AP20793; and (b) coupling the AP20793 so produced with API7362 to yield AP20187. In particular embodiments, the method further includes the step of producing API7362 by coupling API7360 with methyl-L-pipecolic acid, or a salt thereof.

Inventors:
LI, Feng (7 New Meadows Road, Winchester, MA, 01890, US)
WANG, Yihan (45 Madison Avenue, Newton, MA, 02460, US)
Application Number:
US2012/022642
Publication Date:
August 02, 2012
Filing Date:
January 26, 2012
Export Citation:
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Assignee:
ARIAD PHARMACEUTICALS, INCORPORATED (26 Landsdowne Street, Cambridge, MA, 02139, US)
LI, Feng (7 New Meadows Road, Winchester, MA, 01890, US)
WANG, Yihan (45 Madison Avenue, Newton, MA, 02460, US)
International Classes:
C07D319/06
Foreign References:
US5580993A1996-12-03
US6417403B12002-07-09
Other References:
ANNENKOV ET AL.: 'Synthesis of Biomimetic Polyamines.' ARKIVOC vol. XIII, 2009, pages 116 - 130
Attorney, Agent or Firm:
ELLISON, Jeffrey J. (Clark & Elbing LLP, 101 Federal StreetBoston, MA, 02110, US)
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