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Patent Searching and Data


Title:
METHODS AND COMPOSITIONS FOR SYNTHESIZING IMPROVED SILK FIBERS
Document Type and Number:
WIPO Patent Application WO/2015/042164
Kind Code:
A3
Abstract:
The present disclosure provides methods and compositions for directed to synthetic block copolymer proteins, expression constructs for their secretion, recombinant microorganisms for their production, and synthetic fibers (including advantageously, microfibers) comprising these proteins that recapitulate many properties of natural silk. The recombinant microorganisms can be used for the commercial production of silk-like fibers.

Inventors:
TURNER BRENDAN (US)
WRAY LINDSAY (US)
WIDMAIER DANIEL M (US)
BRESLAUER DAVID N (US)
KITTLESON JOSH (US)
Application Number:
PCT/US2014/056117
Publication Date:
May 14, 2015
Filing Date:
September 17, 2014
Export Citation:
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Assignee:
BOLT THREADS INC (US)
TURNER BRENDAN (US)
WRAY LINDSAY (US)
International Classes:
A61K47/30; A61K47/00; A61K47/32; C12N1/20; C12P1/00; C12P21/06
Foreign References:
US20050010035A12005-01-13
US20130109762A12013-05-02
US20100222553A12010-09-02
US20100068517A12010-03-18
US20130212718A12013-08-15
US20050054830A12005-03-10
Other References:
PAAL ET AL.: "A novel Ecotin-Ubiquitin-Tag (ECUT) for efficient, soluble peptide production in the periplasm of Escherichia coli.", MICROBIAL CELL FACTORIES, vol. 8, no. 7, 21 January 2009 (2009-01-21), pages 1 - 9, XP021049899
COLLINS ET AL.: "Batch production of a silk-elastin-like protein in E. coli BL21 ( DE 3): key parameters for optimisation.", MICROBIAL CELL FACTORIES, vol. 12, no. 21, 27 February 2013 (2013-02-27), pages 1 - 16, XP021146868
Attorney, Agent or Firm:
KIM, Jane, N. et al. (Silicon Valley Center801 California Stree, Mountain View CA, US)
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