Title:
METHODS, COMPOSITIONS, AND SYSTEMS FOR ACTIVATION AND EXPANSION OF CELLS
Document Type and Number:
WIPO Patent Application WO/2015/157664
Kind Code:
A3
Abstract:
The disclosure provides for compositions, systems, and methods of cell expansion, stimulation and/or differentiation. The disclosure further provides for a mesh substrate and associated methods capable of stimulating cell expansion, for example, T cell or stem cell expansion. In another aspect, the disclosure provides for an electrospun mesh substrate and methods of using thereof comprising a silicone rubber composition, for example, polydimethylsiloxane, PLC, or combinations thereof.
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Inventors:
KAM LANCE C (US)
LU HELEN H (US)
DE LEO SARAH E (US)
BASHOUR KEENAN T (US)
BOGDANOWICZ DANIELLE (US)
CHUANG PHILIP (US)
LU HELEN H (US)
DE LEO SARAH E (US)
BASHOUR KEENAN T (US)
BOGDANOWICZ DANIELLE (US)
CHUANG PHILIP (US)
Application Number:
PCT/US2015/025355
Publication Date:
March 17, 2016
Filing Date:
April 10, 2015
Export Citation:
Assignee:
UNIV COLUMBIA (US)
International Classes:
C12N5/00
Domestic Patent References:
| WO2014145745A1 | 2014-09-18 |
Foreign References:
| GB2504996A | 2014-02-19 |
Other References:
RAO SHREYAS S ET AL: "Mimicking white matter tract topography using core-shell electrospun nanofibers to examine migration of malignant brain tu", BIOMATERIALS, vol. 34, no. 21, 16 April 2013 (2013-04-16), pages 5181 - 5190, XP028593852, ISSN: 0142-9612, DOI: 10.1016/J.BIOMATERIALS.2013.03.069
DANIELLE R BOGDANOWICZ ET AL: "Poly(dimethyl siloxane)-Containing Nanofiber Meshes as a Platform for Studying Stem Cell Behavior", 1 January 2015 (2015-01-01), XP055241563, Retrieved from the Internet [retrieved on 20160114]
DANIELLE R BOGDANOWICZ ET AL: "Poly(dimethyl siloxane)-Containing Nanofiber Meshes as a Platform for Studying Stem Cell Behavior", 1 January 2015 (2015-01-01), XP055241563, Retrieved from the Internet
Attorney, Agent or Firm:
CATAN, Mark, A. et al. (PC1751 Pinnacle Drive, Suite 150, Tysons Corner VA, US)
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