Title:
METHODS AND COMPOSITIONS FOR TARGETED PROTEIN DEGRADATION
Document Type and Number:
WIPO Patent Application WO/2022/078350
Kind Code:
A1
Abstract:
Provided are compounds of Formula (I) and pharmaceutically acceptable salts and compositions thereof, which are useful for treating cancers and related conditions.
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Inventors:
YING WEIWEN (US)
FOLEY KEVIN PAUL (US)
YIN WEI (CN)
YE LONG (CN)
WANG MINGKAI (CN)
YING CHENGHAO (CN)
ZHANG LINGJIE (CN)
FOLEY KEVIN PAUL (US)
YIN WEI (CN)
YE LONG (CN)
WANG MINGKAI (CN)
YING CHENGHAO (CN)
ZHANG LINGJIE (CN)
Application Number:
PCT/CN2021/123366
Publication Date:
April 21, 2022
Filing Date:
October 12, 2021
Export Citation:
Assignee:
RANOK THERAPEUTICS HANGZHOU CO LTD (CN)
International Classes:
C07D487/04; A61K31/55; A61P35/00; C07D401/14; C07D403/04; C07D403/14; C07D513/04
Domestic Patent References:
WO2021061894A1 | 2021-04-01 | |||
WO2016105518A1 | 2016-06-30 | |||
WO2017007612A1 | 2017-01-12 | |||
WO2017024317A2 | 2017-02-09 | |||
WO2018148440A1 | 2018-08-16 | |||
WO2014145909A2 | 2014-09-18 | |||
WO2014160430A1 | 2014-10-02 |
Foreign References:
US20190151457A1 | 2019-05-23 | |||
US20190315753A1 | 2019-10-17 | |||
US20170008888A1 | 2017-01-12 |
Other References:
FERGUSON FLEUR M., LIU YAN, HARSHBARGER WAYNE, HUANG LING, WANG JINHUA, DENG XIANMING, CAPUZZI STEPHEN J., MURATOV EUGENE N., TROP: "Synthesis and Structure–Activity Relationships of DCLK1 Kinase Inhibitors Based on a 5,11-Dihydro-6 H -benzo[ e ]pyrimido[5,4- b ][1,4]diazepin-6-one Scaffold", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 63, no. 14, 23 July 2020 (2020-07-23), US , pages 7817 - 7826, XP055921966, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.0c00596
WANG JINHUA, ERAZO TATIANA, FERGUSON FLEUR M., BUCKLEY DENNIS L., GOMEZ NESTOR, MUÑOZ-GUARDIOLA PAU, DIÉGUEZ-MARTÍNEZ NORA, DENG X: "Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains", ACS CHEMICAL BIOLOGY, vol. 13, no. 9, 21 September 2018 (2018-09-21), pages 2438 - 2448, XP055921970, ISSN: 1554-8929, DOI: 10.1021/acschembio.7b00638
WANG JINHUA, ERAZO TATIANA, FERGUSON FLEUR M., BUCKLEY DENNIS L., GOMEZ NESTOR, MUÑOZ-GUARDIOLA PAU, DIÉGUEZ-MARTÍNEZ NORA, DENG X: "Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains", ACS CHEMICAL BIOLOGY, vol. 13, no. 9, 21 September 2018 (2018-09-21), pages 2438 - 2448, XP055921970, ISSN: 1554-8929, DOI: 10.1021/acschembio.7b00638
Attorney, Agent or Firm:
KING & WOOD MALLESONS (CN)
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