METHODS, COMPOSITIONS AND THERAPEUTIC APPLICATIONS RELATING TO FORTILIN (= TRANSLATIONALLY CONTROLLED TUMOR PROTEIN, TCTP) AND MODULATORS THEREOF

WIPO Patent Application WO2002036624

A9

The polypeptide Fortilin (also known as Translationally Controlled Tumour Protein, TCTP) specifically interacts with p53, a tumor suppressor involved in the induction of apoptosis and the normal growth regulation of a cell. Fortilin also specifically binds MCL1 (Myeloid Cell Leukemia 1). Fortilin has the ability to prevent apoptosis, which may be unregulated in hyperproliferative cells. The present invention is directed at compositions and methods involving a Fortilin modulator, which can induce apoptosis, for the prevention, treatment, or diagnosis of hyperproliferative diseases and conditions, including cancer and atherosclerosis. It is directed also at compositions and methods involving Fortilin, which can inhibit apoptosis, for the treatment of diseases and condition characterized by apoptosis, including certain vascular conditions.

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FUJISE KENICHI (US)
YEH EDWARD (US)

PCT/US2001/042985

November 20, 2003

October 30, 2001

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UNIV TEXAS (US)
FUJISE KENICHI (US)
YEH EDWARD (US)

A61K38/17; C07K14/47; C07K16/18; C07K16/22; C12Q1/68; C12Q1/6886; G01N33/574; G01N33/68; (IPC1-7): C12Q1/68; A61K31/70; A61K39/395; A61K38/17; G01N33/50; A61P9/10; A61P35/00; A61P25/00

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