Title:
METHODS AND COMPOSITIONS FOR TREATING AGING-ASSOCIATED IMPAIRMENTS
Document Type and Number:
WIPO Patent Application WO/2016/187217
Kind Code:
A3
Abstract:
Methods of treating an adult mammal for an aging-associated impairment are provided. Aspects of the methods include reducing the 2-microglobulin (B2M) level in the mammal in a manner sufficient to treat the mammal for the aging-associated impairment. A variety of aging-associated impairments may be treated by practice of the methods, which impairments include cognitive impairments.
Inventors:
WYSS-CORAY ANTON (US)
VILLEDA SAUL A (US)
NIKOLICH KAROLY (US)
VILLEDA SAUL A (US)
NIKOLICH KAROLY (US)
Application Number:
PCT/US2016/032907
Publication Date:
January 05, 2017
Filing Date:
May 17, 2016
Export Citation:
Assignee:
UNIV LELAND STANFORD JUNIOR (US)
UNIV CALIFORNIA (US)
ALKAHEST INC (US)
UNIV CALIFORNIA (US)
ALKAHEST INC (US)
International Classes:
A61K39/395; A61M1/16; A61K48/00; B01D11/00; C12N15/11
Foreign References:
| US20140255424A1 | 2014-09-11 | |||
| US20100258496A1 | 2010-10-14 | |||
| US20020143283A1 | 2002-10-03 | |||
| US20040127445A1 | 2004-07-01 |
Other References:
CHEUNG ET AL.: "Serum b-2 microglobulin predicts mortality in people with diabetes.", EUR J ENDOCRINOL., vol. 169, no. 1, 2013, pages 1 - 7, XP055341396
LYSAGHT ET AL.: "Beta-2 Microglobulin Removal During Continuous Ambulatory Peritoneal Dialysis (CAPD).", PERIT DIAL INT., vol. 9, no. 1, 1989, pages 29 - 35, XP055500715
SMITH ET AL.: "beta.2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis.", NAT MED., vol. 21, no. 8, 2015, pages 932 - 7, XP055341426
LYSAGHT ET AL.: "Beta-2 Microglobulin Removal During Continuous Ambulatory Peritoneal Dialysis (CAPD).", PERIT DIAL INT., vol. 9, no. 1, 1989, pages 29 - 35, XP055500715
SMITH ET AL.: "beta.2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis.", NAT MED., vol. 21, no. 8, 2015, pages 932 - 7, XP055341426
Attorney, Agent or Firm:
FIELD, Bret E. (US)
Download PDF:
Previous Patent: ANTI-ROR1 CHIMERIC ANTIGEN RECEPTORS
Next Patent: INTRAVASCULAR IMAGING SYSTEM INTERFACES AND SHADOW DETECTION METHODS
Next Patent: INTRAVASCULAR IMAGING SYSTEM INTERFACES AND SHADOW DETECTION METHODS