Title:
METHODS AND COMPOSITIONS FOR TREATING HEPATITIS WITH ANTI-CD3 IMMUNE MOLECULE THERAPY
Document Type and Number:
WIPO Patent Application WO/2011/135544
Kind Code:
A3
Abstract:
A method or composition comprising an anti-CD3 immune molecule for treatment of hepatitis in a subject.
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Inventors:
ILAN YARON (IL)
ELLIS RONALD (IL)
ELLIS RONALD (IL)
Application Number:
PCT/IB2011/051900
Publication Date:
January 05, 2012
Filing Date:
April 29, 2011
Export Citation:
Assignee:
NASVAX LTD (IL)
HADASIT MEDICAL RES SERVICE AND DEV CO LTD (IL)
ILAN YARON (IL)
ELLIS RONALD (IL)
HADASIT MEDICAL RES SERVICE AND DEV CO LTD (IL)
ILAN YARON (IL)
ELLIS RONALD (IL)
International Classes:
C07K16/28; A61P1/16
Domestic Patent References:
| WO2009090656A2 | 2009-07-23 | |||
| WO2001037860A1 | 2001-05-31 | |||
| WO2005048935A2 | 2005-06-02 |
Other References:
ORENBUCH-HARROCH E ET AL: "41 ORAL ADMINISTRATION OF ANTI CD3-MONOCLONAL ANTIBODIES PROMOTES CD4+CD25+ LAP+ AND NKT LAP+ REGULATORY T LYMPHOCYTES AND AMELIORATES HEPATITIS BY INHIBITING CASPASE 3-MEDIATED APOPTOSIS", JOURNAL OF HEPATOLOGY, MUNKSGAARD INTERNATIONAL PUBLISHERS, COPENHAGEN, DK, vol. 50, 1 April 2009 (2009-04-01), pages S18, XP026495654, ISSN: 0168-8278, [retrieved on 20090401], DOI: 10.1016/S0168-8278(09)60043-X
ORENBUCH-HARROCH EFRAT ET AL: "PROMOTION OF THE EXPRESSION OF LAP ON NKT LYMPHOCYTES BY ORAL ADMINISTRATION OF ANTI CD3 MONOCLONAL ANTIBODIES ALLEVIATES IMMUNE MEDIATED HEPATITIS: A NOVEL METHOD FOR INDUCTION OF REGULATORY T CELLS", HEPATOLOGY, vol. 50, no. 4, Suppl. S, October 2009 (2009-10-01), & 60TH ANNUAL MEETING OF THE AMERICAN-ASSOCIATION-FOR-THE-STUDY-OF-LIVE R-DISEASES; BOSTON, MA, USA; OCTOBER 30 -NOVEMBER 03, 2009, pages 863A, XP009153179, ISSN: 0270-9139
OCHI H ET AL: "New immunosuppressive approaches: Oral administration of CD3-specific antibody to treat autoimmunity", JOURNAL OF NEUROLOGICAL SCIENCES, ELSEVIER SCIENTIFIC PUBLISHING CO, AMSTERDAM, NL, vol. 274, no. 1-2, 15 November 2008 (2008-11-15), pages 9 - 12, XP025504753, ISSN: 0022-510X, [retrieved on 20080918], DOI: 10.1016/J.JNS.2008.07.027
YOUNOSSI Z M: "Review article: current management of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis", ALIMENTARY PHARMACOLOGY & THERAPEUTICS, vol. 28, no. 1, July 2008 (2008-07-01), pages 2 - 12, XP002661670, ISSN: 0269-2813
YANG ROLAND ET AL: "MONOCLONAL ANTI-CD3 TREATMENT FOR TYPE 2 AUTOIMMUNE HEPATITIS IN AN EXPERIMENTAL MODEL", HEPATOLOGY, vol. 52, no. 4, Suppl. S, October 2010 (2010-10-01), & 61ST ANNUAL MEETING OF THE AMERICAN-ASSOCIATION-FOR-THE-STUDY-OF-LIVE R-DISEASES; BOSTON, MA, USA; OCTOBER 29 -NOVEMBER 02, 2010, pages 614A, XP009153213, ISSN: 0270-9139
ILAN YARON ET AL: "Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 107, no. 21, May 2010 (2010-05-01), pages 9765 - 9770, XP002661672, ISSN: 0027-8424
ORENBUCH-HARROCH EFRAT ET AL: "PROMOTION OF THE EXPRESSION OF LAP ON NKT LYMPHOCYTES BY ORAL ADMINISTRATION OF ANTI CD3 MONOCLONAL ANTIBODIES ALLEVIATES IMMUNE MEDIATED HEPATITIS: A NOVEL METHOD FOR INDUCTION OF REGULATORY T CELLS", HEPATOLOGY, vol. 50, no. 4, Suppl. S, October 2009 (2009-10-01), & 60TH ANNUAL MEETING OF THE AMERICAN-ASSOCIATION-FOR-THE-STUDY-OF-LIVE R-DISEASES; BOSTON, MA, USA; OCTOBER 30 -NOVEMBER 03, 2009, pages 863A, XP009153179, ISSN: 0270-9139
OCHI H ET AL: "New immunosuppressive approaches: Oral administration of CD3-specific antibody to treat autoimmunity", JOURNAL OF NEUROLOGICAL SCIENCES, ELSEVIER SCIENTIFIC PUBLISHING CO, AMSTERDAM, NL, vol. 274, no. 1-2, 15 November 2008 (2008-11-15), pages 9 - 12, XP025504753, ISSN: 0022-510X, [retrieved on 20080918], DOI: 10.1016/J.JNS.2008.07.027
YOUNOSSI Z M: "Review article: current management of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis", ALIMENTARY PHARMACOLOGY & THERAPEUTICS, vol. 28, no. 1, July 2008 (2008-07-01), pages 2 - 12, XP002661670, ISSN: 0269-2813
YANG ROLAND ET AL: "MONOCLONAL ANTI-CD3 TREATMENT FOR TYPE 2 AUTOIMMUNE HEPATITIS IN AN EXPERIMENTAL MODEL", HEPATOLOGY, vol. 52, no. 4, Suppl. S, October 2010 (2010-10-01), & 61ST ANNUAL MEETING OF THE AMERICAN-ASSOCIATION-FOR-THE-STUDY-OF-LIVE R-DISEASES; BOSTON, MA, USA; OCTOBER 29 -NOVEMBER 02, 2010, pages 614A, XP009153213, ISSN: 0270-9139
ILAN YARON ET AL: "Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 107, no. 21, May 2010 (2010-05-01), pages 9765 - 9770, XP002661672, ISSN: 0027-8424
Attorney, Agent or Firm:
DR. D. GRAESER LTD. et al. (13 Hasadna St, Raanana, IL)
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