Title:
METHODS AND COMPOSITIONS FOR TREATING HYPERTENSION, ANGINA AND OTHER DISORDERS USING OPTICALLY PURE (-) AMLODIPINE
Document Type and Number:
WIPO Patent Application WO/1993/010779
Kind Code:
A1
Abstract:
Methods and compositions are disclosed utilizing the optically pure (-) isomer of amlodipine. This compound is a potent drug for the treatment of hypertension while avoiding the concomitant liability of adverse effects associated with the racemic mixture of amlodipine. The (-) isomer of amlodipine is also useful for the treatment of angina and such other conditions as may be related to the activity of (-) amlodipine as a calcium channel antagonist such as cerebral ischemia, cerebral disorders, arrhythmias, cardiac hypertrophy, coronary vasospasm, myocardial infarction, renal impairment and acute renal failure, without the concomitant liability of adverse effects associated with the racemic mixture of amlodipine.
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Inventors:
YOUNG JAMES W (US)
Application Number:
PCT/US1992/010145
Publication Date:
June 10, 1993
Filing Date:
November 25, 1992
Export Citation:
Assignee:
SEPRACOR INC (US)
International Classes:
A61K31/44; A61P9/00; A61P9/06; A61P9/08; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P13/02; A61P15/00; A61P25/06; A61P25/08; A61P25/28; (IPC1-7): A61K31/44
Other References:
"The Merck Index", published 1989 by Merck & Co., Inc. (Rahway, N.J.), No. 509.
A.R. GENNARO, Ed., "Remington's Pharmaceutical Sciences, 18th Ed.", published 1990 by Mack Publishing Co. (Easton, PA), pages 853-854.
See also references of EP 0661970A4
A.R. GENNARO, Ed., "Remington's Pharmaceutical Sciences, 18th Ed.", published 1990 by Mack Publishing Co. (Easton, PA), pages 853-854.
See also references of EP 0661970A4
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