Title:
METHODS AND COMPOSITIONS FOR TREATING INSECTS
Document Type and Number:
WIPO Patent Application WO/2011/017137
Kind Code:
A3
Abstract:
Provided herein are methods and compositions for modulating gene expression in insects by administering a composition comprising an RNA effector molecule and a delivery agent. Methods are provided for controlling pest populations by inhibiting insect growth, development, survival, reproduction and/or viability. Also provided herein are methods for treating or preventing disease in an insect caused by a pathogen or by external factors (e.g., pollution, environment, stress, weather, etc.).
Inventors:
WARD DONNA (US)
RHODES JASON (US)
RHODES JASON (US)
Application Number:
PCT/US2010/043458
Publication Date:
April 21, 2011
Filing Date:
July 28, 2010
Export Citation:
Assignee:
ALNYLAM PHARMACEUTICALS INC (US)
WARD DONNA (US)
RHODES JASON (US)
WARD DONNA (US)
RHODES JASON (US)
International Classes:
C07H21/02; A61K31/7115
Domestic Patent References:
| WO2006129204A2 | 2006-12-07 |
Foreign References:
| US20090118214A1 | 2009-05-07 | |||
| US20030055020A1 | 2003-03-20 | |||
| US6326193B1 | 2001-12-04 | |||
| US20070219131A1 | 2007-09-20 | |||
| US20030224041A1 | 2003-12-04 |
Other References:
ZIMMERMAN ET AL.: "The role of ARK in stress-induced apoptosis in Drosophila cells.", THE JOURNAL OF CELL BIOLOGY, vol. 156, no. 6, 18 March 2002 (2002-03-18), pages 1077 - 1087, XP008151795
ALLERSON ET AL.: "Fully 2'-Modified Oligonucleotide Duplexes with Improved in Vitro Potency and Stability Compared to Unmodified Small Interfering RNA.", J. MED. CHEM., vol. 48, no. 4, 24 February 2005 (2005-02-24), pages 901 - 904, XP002404763
MULTINELLI: "Practical Application of Antibacterial Drugs for the Control of Honeybee Disease.", APIACTA, vol. 38, 2003, pages 149 - 155, XP008151965
ALLERSON ET AL.: "Fully 2'-Modified Oligonucleotide Duplexes with Improved in Vitro Potency and Stability Compared to Unmodified Small Interfering RNA.", J. MED. CHEM., vol. 48, no. 4, 24 February 2005 (2005-02-24), pages 901 - 904, XP002404763
MULTINELLI: "Practical Application of Antibacterial Drugs for the Control of Honeybee Disease.", APIACTA, vol. 38, 2003, pages 149 - 155, XP008151965
Attorney, Agent or Firm:
RESNICK, David et al. (100 Summer StreetBoston, Massachusetts, US)
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