METHODS AND COMPOSITIONS FOR TREATING MALIGNANT TUMORS

Title:

METHODS AND COMPOSITIONS FOR TREATING MALIGNANT TUMORS

Document Type and Number:

WIPO Patent Application WO/2018/151840

Kind Code:

A3

Abstract:

This invention provides methods and compositions for preventing, treating or ameliorating one or more symptoms of a malignant tumor associated with KRAS mutation in a mammal in need thereof, by identifying a tumor cell in the mammal, the tumor cell comprising at least one of: (i) a mutation of the KRAS gene, and (ii) an aberrant expression level of KRAS protein; and administering to the mammal a therapeutically effective amount of a composition comprising one or more RNAi molecules that are active in reducing expression of GST-π.

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Inventors:

YING WENBIN (US)
MINOMI KENJIROU (JP)
LIU JIHUA (US)
WANG LI (US)
MAJETI BHARAT (US)
ADAMI ROGER (US)

Application Number:

PCT/US2018/000054

Publication Date:

October 11, 2018

Filing Date:

February 16, 2018

Export Citation:

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Assignee:

NITTO DENKO CORP (JP)
YING WENBIN (US)

International Classes:

A61K31/7088; A61K31/105; A61K47/14; A61K47/44; C12N15/113; C12Q1/68; G01N33/574

Foreign References:

US20160186182A1	2016-06-30
US20160186183A1	2016-06-30

Attorney, Agent or Firm:

ECKMAN, Richard, R. (US)

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