Title:
METHODS AND COMPOSITIONS FOR TREATING PHYTOPATHOGEMETHODS AND COMPOSITIONS FOR TREATING PHYTOPATHOGENIC FUNGI INFECTIONS NIC FUNGI INFECTIONS
Document Type and Number:
WIPO Patent Application WO1996015104
Kind Code:
A3
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Inventors:
BOLONICK JOEL (US)
LEIGHTON TERRANCE J (US)
YU IDA K (US)
LEIGHTON TERRANCE J (US)
YU IDA K (US)
Application Number:
PCT/US1995/014669
Publication Date:
September 19, 1996
Filing Date:
November 09, 1995
Export Citation:
Assignee:
NZYM INC (US)
BOLONICK JOEL (US)
LEIGHTON TERRANCE J (US)
YU IDA K (US)
BOLONICK JOEL (US)
LEIGHTON TERRANCE J (US)
YU IDA K (US)
International Classes:
A01N37/52; A01N43/36; A01N43/38; A01N43/50; A01N47/44; A01N61/00; C07C257/18; C07D207/34; C07D403/12; (IPC1-7): C07C257/18
Domestic Patent References:
| WO1994008580A1 | 1994-04-28 | |||
| WO1992010475A1 | 1992-06-25 | |||
| WO1992020698A1 | 1992-11-26 | |||
| WO1994003434A1 | 1994-02-17 |
Foreign References:
| EP0366066A1 | 1990-05-02 | |||
| US2277861A | 1942-03-31 | |||
| EP0375414A1 | 1990-06-27 | |||
| DE3606294A1 | 1986-10-09 | |||
| US3190801A | 1965-06-22 | |||
| US4912199A | 1990-03-27 | |||
| US4738980A | 1988-04-19 |
Other References:
JONES,S.K. ET AL.: "Novel Pentamidine Analogs in the Treatment of Experimental Pneumocystis carnii Pneumonia", ANTIMICROB. AGENTS CHEMOTHER., vol. 34, no. 6, June 1990 (1990-06-01), pages 1026 - 1030, XP002007932
DONKOR,I.O. ET AL.: "Pentamidine Congeners 1. Synthesis of Cis- and Trans-Butamidine Analogues As Anti-Pneumocystis carinii Pneumonia Agents", BIOORG.&MED.CHEM.LETT., vol. 3, no. 6, 1993, pages 1137 - 1140, XP002007933
CORY,M. ET AL.: "Structure and DNA Binding Activity of Analogues of 1,5-Bis(4-amidinophenoxy)pentane (Pentamidine)", J.MED.CHEM., vol. 35, no. 3, 1992, WASHINGTON, pages 431 - 438, XP002007934
PILCH,D.S. ET AL.: "Berenil [1,3-Bis-(4'-aimidinophenyl)triazene] Binding to DNA Duplexes and to a RNA Duplex : Evidence for Both Intercalative and Mior Groove Binding Properties", BIOCHEMISTRY, vol. 34, no. 31, 8 August 1995 (1995-08-08), pages 9962 - 9976, XP002007935
HUDSON,H.R. ET AL.: "Guanidines with antifungal ( and antibacterial ) activity - a review", INT.PEST CONTROL, November 1986 (1986-11-01), LONDON, pages 148 - 155, XP002007936
ZIMMER,C. ET AL.: "Nonintercalating DNA-Binding Ligands: Specifity of the Interaction and their use as tools in Biophysical, Biochemical and Biological Investigations of the Genetic Material", PROG.BIOPHYS.MOLEC.BIOL., vol. 47, 1986, OXFORD, pages 31 - 112, XP002007938
DEBART,F .ET AL: "Synthesis, DNA Binding, and Biological Evaluation of Synthetic Precursors and Novel Analogues of Netropsin", J.MED.CHEM., vol. 32, no. 5, 1989, WASHINGTON, pages 1074 - 1083, XP002008332
GEIERSTANGER,B.H. ET AL: "Design of a G.C-Specific DNA Minor Groove Binding Peptide", SCIENCE, vol. 266, 18 October 1994 (1994-10-18), WASHINGTON, pages 646 - 650, XP002007937
GREHN,L. ET AL.: "The Preparation and Properties of Partially Protected 4-Amino-1-methylimidazole-2-carboxylic Acids to be used as Intermediates in the Synthesis of Analogues of Distamycin A", ACTA CHEM.SCAND., vol. 44, January 1990 (1990-01-01), COPENHAGEN, pages 67 - 74, XP002007939
WADE,W.S. ET AL.: "Design of Peptides That Bind in the Minor Groove of DNA at 5'-(A,T)G(A,T)C(A,T)-3' Sequences by a Dimeric Side-by-Side Motif", J.AM.CHEM.SOC., vol. 114, 1992, WASHINGTON, pages 8783 - 8794, XP002007940
DONKOR,I.O. ET AL.: "Pentamidine Congeners 1. Synthesis of Cis- and Trans-Butamidine Analogues As Anti-Pneumocystis carinii Pneumonia Agents", BIOORG.&MED.CHEM.LETT., vol. 3, no. 6, 1993, pages 1137 - 1140, XP002007933
CORY,M. ET AL.: "Structure and DNA Binding Activity of Analogues of 1,5-Bis(4-amidinophenoxy)pentane (Pentamidine)", J.MED.CHEM., vol. 35, no. 3, 1992, WASHINGTON, pages 431 - 438, XP002007934
PILCH,D.S. ET AL.: "Berenil [1,3-Bis-(4'-aimidinophenyl)triazene] Binding to DNA Duplexes and to a RNA Duplex : Evidence for Both Intercalative and Mior Groove Binding Properties", BIOCHEMISTRY, vol. 34, no. 31, 8 August 1995 (1995-08-08), pages 9962 - 9976, XP002007935
HUDSON,H.R. ET AL.: "Guanidines with antifungal ( and antibacterial ) activity - a review", INT.PEST CONTROL, November 1986 (1986-11-01), LONDON, pages 148 - 155, XP002007936
ZIMMER,C. ET AL.: "Nonintercalating DNA-Binding Ligands: Specifity of the Interaction and their use as tools in Biophysical, Biochemical and Biological Investigations of the Genetic Material", PROG.BIOPHYS.MOLEC.BIOL., vol. 47, 1986, OXFORD, pages 31 - 112, XP002007938
DEBART,F .ET AL: "Synthesis, DNA Binding, and Biological Evaluation of Synthetic Precursors and Novel Analogues of Netropsin", J.MED.CHEM., vol. 32, no. 5, 1989, WASHINGTON, pages 1074 - 1083, XP002008332
GEIERSTANGER,B.H. ET AL: "Design of a G.C-Specific DNA Minor Groove Binding Peptide", SCIENCE, vol. 266, 18 October 1994 (1994-10-18), WASHINGTON, pages 646 - 650, XP002007937
GREHN,L. ET AL.: "The Preparation and Properties of Partially Protected 4-Amino-1-methylimidazole-2-carboxylic Acids to be used as Intermediates in the Synthesis of Analogues of Distamycin A", ACTA CHEM.SCAND., vol. 44, January 1990 (1990-01-01), COPENHAGEN, pages 67 - 74, XP002007939
WADE,W.S. ET AL.: "Design of Peptides That Bind in the Minor Groove of DNA at 5'-(A,T)G(A,T)C(A,T)-3' Sequences by a Dimeric Side-by-Side Motif", J.AM.CHEM.SOC., vol. 114, 1992, WASHINGTON, pages 8783 - 8794, XP002007940
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