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Patent Searching and Data


Title:
METHODS AND COMPOSITIONS FOR TREATING A SUBJECT FOR CENTRAL NERVOUS SYSTEM (CNS) INJURY
Document Type and Number:
WIPO Patent Application WO/2011/153377
Kind Code:
A3
Abstract:
Methods for treating a central nervous system (CNS) injury in a subject are provided. Aspects of the methods include administering to the subject an effective amount of gamma aminobutyric acid (GABA) receptor signaling inhibitor to treat the subject for the CNS injury. Also provided are compositions useful in embodiments of the methods. Methods and compositions of the invention find use in the treatment of a variety of different CNS injuries, including but not limited to, treating a subject for CNS injury associated with the occurrence of stroke.

Inventors:
CARMICHAEL STANLEY T (US)
MODY ISTVAN (US)
HUANG BEN (US)
CLARKSON ANDREW N (NZ)
Application Number:
PCT/US2011/038965
Publication Date:
January 19, 2012
Filing Date:
June 02, 2011
Export Citation:
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Assignee:
UNIV CALIFORNIA (US)
CARMICHAEL STANLEY T (US)
MODY ISTVAN (US)
HUANG BEN (US)
CLARKSON ANDREW N (NZ)
International Classes:
A01N43/00; A61K31/33
Domestic Patent References:
WO2003006471A12003-01-23
WO2009100040A22009-08-13
WO2006063708A12006-06-22
Other References:
KREHAN ET AL.: "Potent 4-Arylalkyl-Substituted 3-Isothiazolol GABAA Competitive/ Noncompetitive Antagonists: Synthesis and Pharmacology.", J MED CHEM, vol. 49, no. 4, 2006, pages 1388 - 1396, XP055068431, Retrieved from the Internet
SAVIC ET AL.: "PWZ-029, a compound with moderate inverse agonist functional selectivity at GABAA receptors containing alpha 5 subunits, improves passive, but not active, avoidance learning in rats.", BRAIN RESEARCH, vol. 1208, 2008, pages 150 - 159, XP055068432, Retrieved from the Internet
Attorney, Agent or Firm:
SWISS, Gerald, F. et al. (975 Page Mill RoadPalo Alto, California, US)
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